Molluscum Contagiosum Virus: Biology and Immune Response.
Apoptosis
Human
Immune escape
Inhibitory protein
Interferon
Keratinocytes
Lesions
Molluscum contagiosum
Skin
Therapies
Toll-like receptors
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
27
5
2024
pubmed:
27
5
2024
entrez:
27
5
2024
Statut:
ppublish
Résumé
Molluscum contagiosum virus is a poxvirus belonging to the Poxviridae family, which includes Orthopoxvirus, Parapoxvirus, Yantapoxvirus, Molluscipoxvirus, Smallpox virus, Cowpox virus and Monkeypox virus. MCV belongs to the genus Molluscipoxvirus and has a tropism for skin tissue. MCV infects keratinocytes and, after an incubation period of 2 weeks to 6 weeks, causes a breakdown of the skin barrier with the development of papules of variable size depending on the proper functioning of the immune response (both adaptive and acquired). MCV only infects humans and does not cause viraemia. MCV encodes for several inhibitory proteins responsible to circumvent the immune response through different signalling pathways. Individuals who can be infected with MCV are children, immunocompromised individuals such as organ transplant recipients and Human Immunodeficiency Virus (HIV)-infected individuals. Current treatments to manage MCV-induced lesions are different and include the use of immunomodulators, which, however, do not provide an effective response.
Identifiants
pubmed: 38801577
doi: 10.1007/978-3-031-57165-7_10
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-170Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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