Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease.


Journal

Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035

Informations de publication

Date de publication:
27 May 2024
Historique:
received: 18 01 2024
accepted: 07 05 2024
revised: 25 03 2024
medline: 28 5 2024
pubmed: 28 5 2024
entrez: 27 5 2024
Statut: epublish

Résumé

The intestinal wall represents an interactive network regulated by the intestinal epithelium, extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological conditions, the epithelium undergoes constant renewal and forms an integral and selective barrier. Following damage, the healthy epithelium is restored via a series of signalling pathways that result in remodelling of the scaffolding tissue through finely-regulated proteolysis of the ECM by proteases such as matrix metalloproteinases (MMPs). However, chronic inflammation of the gastrointestinal tract, as occurs in Inflammatory Bowel Disease (IBD), is associated with prolonged disruption of the epithelial barrier and persistent damage to the intestinal mucosa. Increased barrier permeability exhibits distinctive signatures of inflammatory, immunological and ECM components, accompanied by increased ECM proteolytic activity. This narrative review aims to bring together the current knowledge of the interplay between gut barrier, immune and ECM features in health and disease, discussing the role of barrier permeability as a discriminant between homoeostasis and IBD.

Identifiants

pubmed: 38802341
doi: 10.1038/s41420-024-02015-1
pii: 10.1038/s41420-024-02015-1
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

258

Subventions

Organisme : Wellcome Trust (Wellcome)
ID : 210911/Z/18/Z
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/T00746X/1

Informations de copyright

© 2024. The Author(s).

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Auteurs

Aurora Vilardi (A)

Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, United Kingdom.

Stefan Przyborski (S)

Department of Biosciences, Durham University, Durham, DH1 3LE, United Kingdom.

Claire Mobbs (C)

Department of Biosciences, Durham University, Durham, DH1 3LE, United Kingdom.

Alessandro Rufini (A)

Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, United Kingdom. Alessandro.Rufini@unimi.it.
Department of Biosciences, University of Milan, Milan, 20133, Italy. Alessandro.Rufini@unimi.it.

Cristina Tufarelli (C)

Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, United Kingdom. cristina.tufarelli@leicester.ac.uk.

Classifications MeSH