Exposure to environmental pollutants selects for xenobiotic-degrading functions in the human gut microbiome.

Humans Gastrointestinal Microbiome / drug effects Xenobiotics / metabolism Environmental Pollutants / metabolism Female Male Feces / microbiology Italy Adult Middle Aged Environmental Exposure / adverse effects Metagenomics / methods Bacteria / genetics Cohort Studies Metals, Heavy / toxicity Aged Environmental Pollution / adverse effects Biodegradation, Environmental

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 May 2024
Historique:
received: 19 02 2024
accepted: 08 05 2024
medline: 28 5 2024
pubmed: 28 5 2024
entrez: 27 5 2024
Statut: epublish

Résumé

Environmental pollutants from different chemical families may reach the gut microbiome, where they can be metabolized and transformed. However, how our gut symbionts respond to the exposure to environmental pollution is still underexplored. In this observational, cohort study, we aim to investigate the influence of environmental pollution on the gut microbiome composition and potential activity by shotgun metagenomics. We select as a case study a population living in a highly polluted area in Campania region (Southern Italy), proposed as an ideal field for exposomic studies and we compare the fecal microbiome of 359 subjects living in areas with high, medium and low environmental pollution. We highlight changes in gut microbiome composition and functionality that were driven by pollution exposure. Subjects from highly polluted areas show higher blood concentrations of dioxin and heavy metals, as well as an increase in microbial genes related to degradation and/or resistance to these molecules. Here we demonstrate the dramatic effect that environmental xenobiotics have on gut microbial communities, shaping their composition and boosting the selection of strains with degrading capacity. The gut microbiome can be considered as a pivotal player in the environment-health interaction that may contribute to detoxifying toxic compounds and should be taken into account when developing risk assessment models. The study was registered at ClinicalTrials.gov with the identifier NCT05976126.

Identifiants

DOI: 10.1038/s41467-024-48739-7 PMID: 38802370
pubmed: 38802370
doi: 10.1038/s41467-024-48739-7
pii: 10.1038/s41467-024-48739-7
doi:

Substances chimiques

Xenobiotics 0
Environmental Pollutants 0
Metals, Heavy 0

Banques de données

ClinicalTrials.gov
['NCT05976126']

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

4482

Subventions

Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : GR-2016-02362975

Informations de copyright

© 2024. The Author(s).

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Auteurs

Francesca De Filippis (F)

Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100, Portici, Italy.
Task Force on Microbiome Studies, University of Naples Federico II, Corso Umberto I, 40, Napoli, Italy.
Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute, 2, Portici, Italy.
ORCID: 0000-0002-3474-2884

Vincenzo Valentino (V)

Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100, Portici, Italy.
ORCID: 0000-0002-6055-4721

Giuseppina Sequino (G)

Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100, Portici, Italy.

Giorgia Borriello (G)

Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute, 2, Portici, Italy.

Marita Georgia Riccardi (MG)

Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute, 2, Portici, Italy.

Biancamaria Pierri (B)

National Reference Centre for the Analysis and Study of the Correlation between Environment, Animal and Human, Via Salute, 2, Portici, Italy.

Pellegrino Cerino (P)

National Reference Centre for the Analysis and Study of the Correlation between Environment, Animal and Human, Via Salute, 2, Portici, Italy.

Antonio Pizzolante (A)

National Reference Centre for the Analysis and Study of the Correlation between Environment, Animal and Human, Via Salute, 2, Portici, Italy.

Edoardo Pasolli (E)

Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100, Portici, Italy.
Task Force on Microbiome Studies, University of Naples Federico II, Corso Umberto I, 40, Napoli, Italy.

Mauro Esposito (M)

National Reference Centre for the Analysis and Study of the Correlation between Environment, Animal and Human, Via Salute, 2, Portici, Italy.

Antonio Limone (A)

Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute, 2, Portici, Italy.

Danilo Ercolini (D)

Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100, Portici, Italy. ercolini@unina.it.
Task Force on Microbiome Studies, University of Naples Federico II, Corso Umberto I, 40, Napoli, Italy. ercolini@unina.it.
ORCID: 0000-0003-3061-9560

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exposure to environmental pollutants selects...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Exposure to environmental pollutants selects...
questionsmedicales.fr › Préparations pharmaceutiques › Xénobiotique › Exposure to environmental pollutants selects...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Exposure to environmental pollutants selects...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Exposure to environmental pollutants selects...
questionsmedicales.fr › Régions géographiques › Europe › Italie › Exposure to environmental pollutants selects...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Exposure to environmental pollutants selects...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Exposure to environmental pollutants selects...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposure to environmental pollutants selects...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Métagénomique › Exposure to environmental pollutants selects...
questionsmedicales.fr › Bactéries › Exposure to environmental pollutants selects...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Exposure to environmental pollutants selects...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Exposure to environmental pollutants selects...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Exposure to environmental pollutants selects...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposure to environmental pollutants selects...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Assainissement et restauration de l'environnement › Dépollution biologique de l'environnement › Exposure to environmental pollutants selects...