Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.
Humans
Female
Aged
Male
Energy Metabolism
/ physiology
Cross-Sectional Studies
Muscle, Skeletal
/ metabolism
Body Mass Index
Oxidative Phosphorylation
Magnetic Resonance Imaging
Adipose Tissue
/ metabolism
Body Fat Distribution
Mitochondria, Muscle
/ metabolism
Intra-Abdominal Fat
/ metabolism
Aged, 80 and over
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
Jun 2024
Jun 2024
Historique:
revised:
18
01
2024
received:
01
12
2023
accepted:
19
01
2024
medline:
28
5
2024
pubmed:
28
5
2024
entrez:
28
5
2024
Statut:
ppublish
Résumé
The aim of this study was to examine associations of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults. Cross-sectional data from 829 adults ≥70 years of age were used. Abdominal, subcutaneous, and visceral AT and thigh muscle fat infiltration (MFI) were quantified by magnetic resonance imaging. SM mitochondrial energetics were characterized in vivo ( Independent of BMI, total abdominal AT (standardized [Std.] β = -0.21; R Skeletal MFI and abdominal visceral, but not subcutaneous, AT are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and in vivo mitochondrial bioenergetics are attenuated by PA.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1125-1135Subventions
Organisme : NCATS NIH HHS
ID : UL1TR001420
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG021332
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG024827
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG059416
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG066474
Pays : United States
Informations de copyright
© 2024 The Obesity Society.
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