Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study.

asthma diagnosis dyspnea mHealth wheezing

Journal

Clinical and translational allergy
ISSN: 2045-7022
Titre abrégé: Clin Transl Allergy
Pays: England
ID NLM: 101576043

Informations de publication

Date de publication:
Jun 2024
Historique:
revised: 08 04 2024
received: 05 10 2023
accepted: 23 04 2024
medline: 28 5 2024
pubmed: 28 5 2024
entrez: 28 5 2024
Statut: ppublish

Résumé

It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. In this cross-sectional study, we assessed real-world data using the MASK-air We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.

Identifiants

DOI: 10.1002/clt2.12358 PMID: 38804596
pubmed: 38804596
doi: 10.1002/clt2.12358
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e12358

Subventions

Organisme : Liège University
Organisme : Asthma and Rhinitis project of the European Institute of Innovation and Technology Health
Organisme : Structural and Development Funds
Organisme : Région Languedoc Roussillon
Organisme : Provence-Alpes-Côte d'Azur
Organisme : Twinning, European Innovation Partnership on Active and Healthy Ageing
Organisme : DG Santé and DG Connect
Organisme : H2020 and Horizon Europe
Organisme : Espíritu Santo University
Organisme : Samborondon Ecuador
Organisme : Educational grants from Mylan-Viatris
Organisme : Allergologisk Laboratorium København
Organisme : GlaxoSmithKline
Organisme : Novartis
Organisme : Stallergènes-Greer
Organisme : Noucor

Informations de copyright

© 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.

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Auteurs

Bernardo Sousa-Pinto (B)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal.

Gilles Louis (G)

Department of Public Health, University of Liège, Liège, Belgium.
GIGA I3 Research Group, University of Liège, Liège, Belgium.
ORCID: 0000-0001-7111-285X

Rafael J Vieira (RJ)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal.
ORCID: 0000-0003-1834-3055

Wienczyslawa Czarlewski (W)

Medical Consulting Czarlewski, Levallois, France.
MASK-air, Montpellier, France.

Josep M Anto (JM)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Rita Amaral (R)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal.

Ana Sá-Sousa (A)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal.

Luisa Brussino (L)

Department of Medical Sciences, University of Torino, Torino, Italy.
Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy.

G Walter Canonica (GW)

Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Asthma and Allergy Unit, IRCCS Humanitas Research Hospital, Milan, Italy.

Claudia Chaves Loureiro (CC)

Department of Pneumology, Faculty of Medicine, Coimbra University Hospital, Coimbra, Portugal.
Coimbra Institute for Clinical and Biomedical Research, CIBB, Coimbra, Portugal.

Alvaro A Cruz (AA)

Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil.

Bilun Gemicioglu (B)

Department of Pulmonary Diseases, Faculty of Medicine, Istanbul University-Cerrahpaşa, Cerrahpaşa, Istanbul, Turkey.
Institute of Pulmonology and Tuberculosis, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Tari Haahtela (T)

Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Maciej Kupczyk (M)

Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.

Violeta Kvedariene (V)

Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Department of Pathology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Desirée E Larenas-Linnemann (DE)

Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
ORCID: 0000-0002-5713-5331

Nhân Pham-Thi (N)

Ecole Polytechnique de Palaiseau, Palaiseau, France.
IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France.
Université Paris Cité, Paris, France.

Francesca Puggioni (F)

IRCCS Humanitas Research Center, Personalized Medicine Asthma & Allergy, Rozzano, Milan, Italy.

Frederico S Regateiro (FS)

Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Faculty of Medicine, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.
Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.

Jan Romantowski (J)

Department of Allergology, Medical University of Gdańsk, Gdansk, Poland.

Joaquin Sastre (J)

Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain.

Nicola Scichilone (N)

PROMISE Department, University of Palermo, Palermo, Italy.

Luis Taborda-Barata (L)

UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.

Maria Teresa Ventura (MT)

Allergy and Clinical Immunology, University of Bari Medical School, Bari, Italy.
Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy.
ORCID: 0000-0002-2637-4583

Ioana Agache (I)

Faculty of Medicine, Transylvania University Brasov, Brasov, Romania.

Anna Bedbrook (A)

MASK-air, Montpellier, France.
ARIA, Montpellier, France.

Alida Benfante (A)

PROMISE Department, University of Palermo, Palermo, Italy.

Karl C Bergmann (KC)

Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.

Sinthia Bosnic-Anticevich (S)

Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
Macquarie Medical School, Macquarie University, Macquarie Park, New South Wales, Australia.

Matteo Bonini (M)

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
National Heart and Lung Institute (NHLI), Imperial College London, London, UK.

Louis-Philippe Boulet (LP)

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.

Guy Brusselle (G)

Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

Roland Buhl (R)

Department of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany.

Lorenzo Cecchi (L)

SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.

Denis Charpin (D)

Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France.

Elisio M Costa (EM)

CINTESIS@RISE, Biochemistry Lab, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, University of Porto, Porto, Portugal.

Stefano Del Giacco (S)

Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.

Marek Jutel (M)

Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
ALL-MED Medical Research Institute, Wroclaw, Poland.

Ludger Klimek (L)

Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
Center for Rhinology and Allergology, Wiesbaden, Germany.

Piotr Kuna (P)

Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.

Daniel Laune (D)

KYomed INNOV, Montpellier, France.

Mika Makela (M)

Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Mario Morais-Almeida (M)

Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.

Rachel Nadif (R)

Université Paris-Saclay, UVSQ, University Paris-Sud, Villejuif, France.
Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France.

Marek Niedoszytko (M)

UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Department of Allergology, Medical University of Gdańsk, Gdansk, Poland.

Nikolaos G Papadopoulos (NG)

Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.

Alberto Papi (A)

Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
ORCID: 0000-0002-6924-4500

Oliver Pfaar (O)

Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
ORCID: 0000-0003-4374-9639

Daniela Rivero-Yeverino (D)

Servicio de Alergia e Inmunología clínica, Hospital Universitario de Puebla, Puebla, México.

Nicolas Roche (N)

Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France.
Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris, France.
UMR 1016, Institut Cochin, Paris, France.

Boleslaw Samolinski (B)

Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.

Mohamed H Shamji (MH)

National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
NIHR Imperial Biomedical Research Centre, London, UK.
ORCID: 0000-0003-3425-3463

Aziz Sheikh (A)

Usher Institute, The University of Edinburgh, Edinburgh, UK.

Charlotte Suppli Ulrik (CS)

Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Copenhagen, Denmark.
Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Omar S Usmani (OS)

National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Airways Disease Section, Royal Brompton Hospital, London, UK.

Arunas Valiulis (A)

Interdisciplinary Research Group of Human Ecology, Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
European Academy of Paediatrics (EAP/UEMS-SP), Brussel, Belgium.

Arzu Yorgancioglu (A)

Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.

Torsten Zuberbier (T)

Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
ORCID: 0000-0002-1466-8875

Joao A Fonseca (JA)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal.

Benoit Pétré (B)

Department of Public Health, University of Liège, Liège, Belgium.

Renaud Louis (R)

GIGA I3 Research Group, University of Liège, Liège, Belgium.
Department of Pulmonary Medicine, CHU Liège, Liège, Belgium.

Jean Bousquet (J)

MASK-air, Montpellier, France.
ARIA, Montpellier, France.
Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France.
ORCID: 0000-0002-4061-4766
MASK-air think tank-See Section 6.

Classifications MeSH