Fluorescence Lifetime Imaging of Lipid Heterogeneity in the Inner Mitochondrial Membrane with a Super-photostable Environment-Sensitive Probe.
Fluorescence lifetime imaging
Imaging agents
Inner mitochondrial membrane
Lipid heterogeneity
Phosphorus heterocycles
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
28 May 2024
28 May 2024
Historique:
received:
04
03
2024
medline:
28
5
2024
pubmed:
28
5
2024
entrez:
28
5
2024
Statut:
aheadofprint
Résumé
The inner mitochondrial membrane (IMM) undergoes dynamic morphological changes, which are crucial for the maintenance of mitochondrial functions as well as cell survival. As the dynamics of the membrane are governed by its lipid components, a fluorescent probe that can sense spatiotemporal alterations in the lipid properties of the IMM over long periods of time is required to understand mitochondrial physiological functions in detail. Herein, we report a red-emissive IMM-labeling reagent with excellent photostability and sensitivity to its environment, which enables the visualization of the IMM ultrastructure using super-resolution microscopy as well as of the lipid heterogeneity based on the fluorescence lifetime at the single mitochondrion level. Combining the probe and fluorescence lifetime imaging microscopy (FLIM) showed that peroxidation of unsaturated lipids in the IMM by reactive oxygen species caused an increase in the membrane order, which took place prior to mitochondrial swelling.
Identifiants
pubmed: 38804831
doi: 10.1002/anie.202404328
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202404328Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19H02849
Organisme : Japan Society for the Promotion of Science
ID : 23K06101
Organisme : Japan Society for the Promotion of Science
ID : JP22H04926
Organisme : Core Research for Evolutional Science and Technology
ID : JPMJCR21O5
Organisme : Exploratory Research for Advanced Technology
ID : JPMJER2101
Informations de copyright
© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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