Leukemia risk assessment of exposure to low-levels of benzene based on the linearized multistage model.
S-PMA
benzene
multi-stage modeling
risk assessment
t
t-MA
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2024
2024
Historique:
received:
14
12
2023
accepted:
30
04
2024
medline:
29
5
2024
pubmed:
29
5
2024
entrez:
29
5
2024
Statut:
epublish
Résumé
To assess leukemia risk in occupational populations exposed to low levels of benzene. Leukemia incidence data from the Chinese Benzene Cohort Study were fitted using the Linearized multistage (LMS) model. Individual benzene exposure levels, urinary S-phenylmercapturic acid (S-PMA) and trans, trans-muconic acid ( The leukemia risks showed a positive correlation with increasing cumulative concentration in the four exposure groups (excess leukemia risks were 4.34, 4.37, 4.44 and 5.52 × 10 This study demonstrates the utility of the LMS model derived from the Chinese benzene cohort in assessing leukemia risk associated with low-level benzene exposure, and suggests that leukemia risk may occur at cumulative concentrations below 3 mg/m
Identifiants
pubmed: 38807987
doi: 10.3389/fpubh.2024.1355739
pmc: PMC11130436
doi:
Substances chimiques
Benzene
J64922108F
Sorbic Acid
X045WJ989B
S-phenyl-N-acetylcysteine
4775-80-8
muconic acid
3KD92ZL2KH
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1355739Informations de copyright
Copyright © 2024 Jin, Zhu, Wu, Li, Wang, Cheng, Li, Huang and Xing.
Déclaration de conflit d'intérêts
MinyL and DH were employed by the company Tianjin Bohai Chemical Industry Group Co Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.