Establishing connectivity through microdissections of midbrain stimulation-related neural circuits.

DBS VTA deep brain stimulation fiber tractography neuropsychiatric neural circuits ventral tegmental area

Journal

Brain : a journal of neurology
ISSN: 1460-2156
Titre abrégé: Brain
Pays: England
ID NLM: 0372537

Informations de publication

Date de publication:
29 May 2024
Historique:
received: 14 12 2023
revised: 15 03 2024
accepted: 21 04 2024
medline: 29 5 2024
pubmed: 29 5 2024
entrez: 29 5 2024
Statut: aheadofprint

Résumé

Comprehensive understanding of the neural circuits involving the ventral tegmental area is essential for elucidating the anatomo-functional mechanisms governing human behaviour as well as the therapeutic and adverse effects of deep brain stimulation for neuropsychiatric diseases. While the ventral tegmental area has been successfully targeted with deep brain stimulation for different neuropsychiatric diseases, the axonal connectivity of the region has not been fully understood. Here using fiber micro-dissections in human cadaveric hemispheres, population-based high-definition fiber tractography, and previously reported deep brain stimulation hotspots, we find that the ventral tegmental area participates in an intricate network involving the serotonergic pontine nuclei, basal ganglia, limbic system, basal forebrain, and prefrontal cortex, which is implicated in the treatment of obsessive-compulsive disorder, major depressive disorder, Alzheimer's disease, cluster headaches, and aggressive behaviors.

Identifiants

DOI: 10.1093/brain/awae173 PMID: 38808482
pubmed: 38808482
pii: 7684362
doi: 10.1093/brain/awae173
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.

Auteurs

Georgios P Skandalakis (GP)

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.
Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.

Clemens Neudorfer (C)

Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.
MGH Neurosurgery & Center for Neurotechnology and Neurorecovery (CNTR) at MGH Neurology Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Department of Neurology, 10117 Berlin, Germany.

Caitlin A Payne (CA)

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.

Evalina Bond (E)

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.

Armin D Tavakkoli (AD)

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.

Jessica Barrios-Martinez (J)

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Anne C Trutti (AC)

Integrative Model-Based Cognitive Neuroscience Research Unit, University of Amsterdam, Amsterdam, The Netherlands.

Christos Koutsarnakis (C)

Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.

Volker A Coenen (VA)

Department of Stereotactic and Functional Neurosurgery, Medical Center of the University of Freiburg, Freiburg, Germany and Medical Faculty of the University of Freiburg, Freiburg, Germany.
Center for Deep Brain Stimulation, Medical Center of the University of Freiburg, Freiburg, Germany.

Spyridon Komaitis (S)

Queens Medical Center, Nottingham University Hospitals NHS Foundation Trust, Nottingham, United Kingdom.
ORCID: 0000-0002-7250-414X

Constantinos G Hadjipanayis (CG)

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

George Stranjalis (G)

Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.

Fang-Cheng Yeh (FC)

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Layla Banihashemi (L)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

Jennifer Hong (J)

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.
ORCID: 0000-0002-6680-0495

Andres M Lozano (AM)

Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Michael Kogan (M)

Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.

Andreas Horn (A)

Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.
MGH Neurosurgery & Center for Neurotechnology and Neurorecovery (CNTR) at MGH Neurology Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Department of Neurology, 10117 Berlin, Germany.

Linton T Evans (LT)

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.

Aristotelis Kalyvas (A)

Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Classifications MeSH