Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium.
DNA methylation
aging
child
melatonin
receptor
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
29 May 2024
29 May 2024
Historique:
revised:
16
04
2024
received:
24
10
2023
accepted:
19
04
2024
medline:
29
5
2024
pubmed:
29
5
2024
entrez:
29
5
2024
Statut:
aheadofprint
Résumé
Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5-10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14194Subventions
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : HHSN267200603423
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : HHSN267200603424
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : HHSN2672006034
Informations de copyright
© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
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