Snoring-generated fluid droplets as a potential mechanistic link between sleep-disordered breathing and pneumonia.
COVID-19
Pathogenesis
Pneumonia
Respiratory aerosol
Self-infection
Snoring
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
29 May 2024
29 May 2024
Historique:
received:
04
04
2024
accepted:
18
05
2024
medline:
30
5
2024
pubmed:
30
5
2024
entrez:
29
5
2024
Statut:
epublish
Résumé
The soft palate and back of the throat represent vulnerable early infection sites for SARS-CoV-2, influenza, streptococci, and many other pathogens. We demonstrate that snoring causes aerosolization of pharyngeal fluid that covers these surfaces, which previously has escaped detection because the inspired airstream carries the micron-sized droplets into the lung, inaccessible to traditional aerosol detectors. While many of these droplets will settle in the lower respiratory tract, a fraction of the respirable smallest droplets remains airborne and can be detected in exhaled breath. We distinguished these exhaled droplets from those generated by the underlying breathing activity by using a chemical tracer, thereby proving their existence. The direct transfer of pharyngeal fluids and their pathogens into the deep lung by snoring represents a plausible mechanistic link between the previously recognized association between sleep-disordered breathing and pneumonia incidence.
Identifiants
pubmed: 38811937
doi: 10.1186/s12931-024-02856-5
pii: 10.1186/s12931-024-02856-5
doi:
Substances chimiques
Aerosols
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
224Subventions
Organisme : NIDDK NIH HHS
ID : DK075154
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK075154
Pays : United States
Informations de copyright
© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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