Pathogenic role and clinical significance of neutrophils and neutrophil extracellular traps in idiopathic inflammatory myopathies.
Autoimmune diseases
Idiopathic inflammatory myopathies
Low-density granulocytes
Neutrophil extracellular traps
Journal
Clinical and experimental medicine
ISSN: 1591-9528
Titre abrégé: Clin Exp Med
Pays: Italy
ID NLM: 100973405
Informations de publication
Date de publication:
30 May 2024
30 May 2024
Historique:
received:
08
04
2024
accepted:
21
05
2024
medline:
30
5
2024
pubmed:
30
5
2024
entrez:
30
5
2024
Statut:
epublish
Résumé
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune diseases characterized by muscle damage and extramuscular symptoms, including specific skin rash, arthritis, interstitial lung disease, and cardiac involvement. While the etiology and pathogenesis of IIM are not yet fully understood, emerging evidence suggests that neutrophils and neutrophil extracellular traps (NETs) have a role in the pathogenesis. Recent research has identified increased levels of circulating and tissue neutrophils as well as NETs in patients with IIM; these contribute to the activation of the type I and type II interferons pathway. During active IIM disease, myositis-specific antibodies are associated with the formation and incomplete degradation of NETs, leading to damage in the lungs, muscles, and blood vessels of patients. This review focuses on the pathogenic role and clinical significance of neutrophils and NETs in IIM, and it includes a discussion of potential targeted treatment strategies.
Identifiants
pubmed: 38814339
doi: 10.1007/s10238-024-01384-2
pii: 10.1007/s10238-024-01384-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
115Subventions
Organisme : Sichuan Province Science and Technology Support Program
ID : 2021JDRC0045 and 2021YFS0164
Organisme : Sichuan Province Science and Technology Support Program
ID : 2021JDRC0045 and 2021YFS0164
Organisme : Sichuan Province Science and Technology Support Program
ID : 2021JDRC0045 and 2021YFS0164
Organisme : Sichuan Province Science and Technology Support Program
ID : 2021JDRC0045 and 2021YFS0164
Organisme : Sichuan Province Science and Technology Support Program
ID : 2021JDRC0045 and 2021YFS0164
Organisme : Sichuan Province Science and Technology Support Program
ID : 2021JDRC0045 and 2021YFS0164
Informations de copyright
© 2024. The Author(s).
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