The effects of psychotherapy for anhedonia on subcortical brain volumes measured with ultra-high field MRI.

Anhedonia Caudate nucleus Clinical trial Psychotherapy Structural MRI

Journal

Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073

Informations de publication

Date de publication:
28 May 2024
Historique:
received: 21 11 2023
revised: 11 05 2024
accepted: 27 05 2024
medline: 31 5 2024
pubmed: 31 5 2024
entrez: 30 5 2024
Statut: aheadofprint

Résumé

Anhedonia is a transdiagnostic symptom often resistant to treatment. The identification of biomarkers sensitive to anhedonia treatment will aid in the evaluation of novel anhedonia interventions. This is an exploratory analysis of changes in subcortical brain volumes accompanying psychotherapy in a transdiagnostic anhedonic sample using ultra-high field (7-Tesla) MRI. Outpatients with clinically impairing anhedonia (n = 116) received Behavioral Activation Treatment for Anhedonia, a novel psychotherapy, or Mindfulness-Based Cognitive Therapy (ClinicalTrials.gov Identifiers NCT02874534 and NCT04036136). Subcortical brain volumes were estimated via the MultisegPipeline, and regions of interest were the amygdala, caudate nucleus, hippocampus, pallidum, putamen, and thalamus. Bivariate mixed effects models estimated pre-treatment relations between anhedonia severity and subcortical brain volumes, change over time in subcortical brain volumes, and associations between changes in subcortical brain volumes and changes in anhedonia symptoms. As reported previously (Cernasov et al., 2023), both forms of psychotherapy resulted in equivalent and significant reductions in anhedonia symptoms. Pre-treatment anhedonia severity and subcortical brain volumes were not related. No changes in subcortical brain volumes were observed over the course of treatment. Additionally, no relations were observed between changes in subcortical brain volumes and changes in anhedonia severity over the course of treatment. This trial included a modest sample size and did not have a waitlist-control condition or a non-anhedonic comparison group. In this exploratory analysis, psychotherapy for anhedonia was not accompanied by changes in subcortical brain volumes, suggesting that subcortical brain volumes may not be a candidate biomarker sensitive to response to psychotherapy.

Sections du résumé

BACKGROUND BACKGROUND
Anhedonia is a transdiagnostic symptom often resistant to treatment. The identification of biomarkers sensitive to anhedonia treatment will aid in the evaluation of novel anhedonia interventions.
METHODS METHODS
This is an exploratory analysis of changes in subcortical brain volumes accompanying psychotherapy in a transdiagnostic anhedonic sample using ultra-high field (7-Tesla) MRI. Outpatients with clinically impairing anhedonia (n = 116) received Behavioral Activation Treatment for Anhedonia, a novel psychotherapy, or Mindfulness-Based Cognitive Therapy (ClinicalTrials.gov Identifiers NCT02874534 and NCT04036136). Subcortical brain volumes were estimated via the MultisegPipeline, and regions of interest were the amygdala, caudate nucleus, hippocampus, pallidum, putamen, and thalamus. Bivariate mixed effects models estimated pre-treatment relations between anhedonia severity and subcortical brain volumes, change over time in subcortical brain volumes, and associations between changes in subcortical brain volumes and changes in anhedonia symptoms.
RESULTS RESULTS
As reported previously (Cernasov et al., 2023), both forms of psychotherapy resulted in equivalent and significant reductions in anhedonia symptoms. Pre-treatment anhedonia severity and subcortical brain volumes were not related. No changes in subcortical brain volumes were observed over the course of treatment. Additionally, no relations were observed between changes in subcortical brain volumes and changes in anhedonia severity over the course of treatment.
LIMITATIONS CONCLUSIONS
This trial included a modest sample size and did not have a waitlist-control condition or a non-anhedonic comparison group.
CONCLUSIONS CONCLUSIONS
In this exploratory analysis, psychotherapy for anhedonia was not accompanied by changes in subcortical brain volumes, suggesting that subcortical brain volumes may not be a candidate biomarker sensitive to response to psychotherapy.

Identifiants

DOI: 10.1016/j.jad.2024.05.140 PMID: 38815760
pubmed: 38815760
pii: S0165-0327(24)00884-X
doi: 10.1016/j.jad.2024.05.140
pii:
doi:

Banques de données

ClinicalTrials.gov
['NCT02874534', 'NCT04036136']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare they have no competing interests.

Auteurs

Kathryn Gibson (K)

Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA; Duke University School of Nursing, 307 Trent Drive, Durham, NC 27710, USA. Electronic address: kathryn_gibson@med.unc.edu.

Paul Cernasov (P)

Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.

Martin Styner (M)

Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.

Erin C Walsh (EC)

Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.

Jessica L Kinard (JL)

Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27510, USA.

Lisalynn Kelley (L)

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA.

Joshua Bizzell (J)

Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27510, USA.

Rachel Phillips (R)

Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.

Courtney Pfister (C)

Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.

McRae Scott (M)

Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.

Louise Freeman (L)

Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.

Angela Pisoni (A)

Department of Psychology and Neuroscience, Duke University, Durham, NC 27505, USA.

Gabriela A Nagy (GA)

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA.

Jason A Oliver (JA)

Department of Family and Preventative Medicine, University of Oklahoma, Oklahoma City, OK 73117, USA.

Moria Smoski (M)

Department of Psychology and Neuroscience, Duke University, Durham, NC 27505, USA.

Gabriel Dichter (G)

Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA; Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27510, USA.

Classifications MeSH