Penicillin Allergy: Mechanisms, Diagnosis, and Management.
Desensitization
Drug challenge
Hypersensitivity
Penicillin allergy
Skin testing
Journal
The Medical clinics of North America
ISSN: 1557-9859
Titre abrégé: Med Clin North Am
Pays: United States
ID NLM: 2985236R
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
medline:
31
5
2024
pubmed:
31
5
2024
entrez:
30
5
2024
Statut:
ppublish
Résumé
Allergy to penicillin can occur via any of the 4 types of Gel-Coombs hypersensitivity reactions, producing distinct clinical histories and physical examination findings. Treatments include penicillin discontinuation, and depending on the type of reaction, epinephrine, antihistamines, and/or glucocorticoids. Most beta-lactams may be safely used in penicillin-allergic patients, with the possible exception of first-generation and second-generation cephalosporins. Penicillin testing includes skin testing, patch testing, and graded challenge. The selection of the type of testing depends on the clinical setting, equipment availability, and type of hypersensitivity reaction. Desensitization may be used in some cases where treatment with penicillins is essential.
Identifiants
pubmed: 38816110
pii: S0025-7125(23)00127-X
doi: 10.1016/j.mcna.2023.08.009
pii:
doi:
Substances chimiques
Penicillins
0
Anti-Bacterial Agents
0
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
671-685Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.