Inborn Errors of Immunity.

Humans Hematopoietic Stem Cell Transplantation Immunologic Deficiency Syndromes / immunology
Antibiotic prophylaxis Antibody deficiency Combined immunodeficiency Hematopoietic stem cell transplantation Immunodeficiency Immunoglobulin replacement Inborn errors of immunity Recurrent infection(s)

Journal

The Medical clinics of North America
ISSN: 1557-9859
Titre abrégé: Med Clin North Am
Pays: United States
ID NLM: 2985236R

Informations de publication

Date de publication:
Jul 2024
Historique:
medline: 31 5 2024
pubmed: 31 5 2024
entrez: 30 5 2024
Statut: ppublish

Résumé

Inborn errors of immunity occur in 1 in 1000 to 1 in 5000 individuals and are characterized by immune deficiency and immune dysregulation. The primary care provider (PCP) should be familiar with key features of these diagnoses including recurrent and/or severe infections, hyperinflammation, malignancy, and autoimmunity and have a low threshold to refer for evaluation. The PCP can begin a laboratory evaluation before referral by sending a complete blood count (CBC) with differential, antibody levels, vaccine titers, and possibly other tests. Management approaches vary from antibiotic prophylaxis to hematopoietic stem cell transplantation depending on the specific diagnosis.

Identifiants

DOI: 10.1016/j.mcna.2023.08.006 PMID: 38816112
pubmed: 38816112
pii: S0025-7125(23)00124-4
doi: 10.1016/j.mcna.2023.08.006
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

703-718

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Carolyn H Baloh (CH)

Division of Allergy and Clinical Immunology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, 60 Fenwood Road, BTM/Hale Building, 5th Floor, Boston, MA 02115, USA. Electronic address: cbaloh@bwh.harvard.edu.

Hey Chong (H)

Division of Allergy and Immunology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, AOB 3300, Pittsburgh, PA 15224, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inborn Errors of Immunity.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Inborn Errors of Immunity.
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Inborn Errors of Immunity.