Sclerosing well-differentiated liposarcoma: two diagnostically challenging mimicker cases and a literature review.
Desmoid fibromatosis
Imaging
Sclerosing
Well-differentiated liposarcoma
Journal
Skeletal radiology
ISSN: 1432-2161
Titre abrégé: Skeletal Radiol
Pays: Germany
ID NLM: 7701953
Informations de publication
Date de publication:
31 May 2024
31 May 2024
Historique:
received:
10
02
2024
accepted:
23
05
2024
revised:
21
05
2024
medline:
31
5
2024
pubmed:
31
5
2024
entrez:
31
5
2024
Statut:
aheadofprint
Résumé
Liposarcoma is a malignant soft tissue tumor with several subtypes, the most common of which is well-differentiated liposarcoma (WDL) or atypical lipomatous tumor (ALT). WDL/ALTs are further divided into three histological subtypes, including lipoma-like, sclerosing, and inflammatory. While the majority of these tumors are predominantly fatty, the sclerosing variant demonstrates diverse histologic and radiographic characteristics, including variable amounts of fibrosis and fat. Because of this histological variability and relative rarity, the sclerosing WDL/ALT can present diagnostic dilemmas. We present two cases of sclerosing WDL/ALT, both of which demonstrated high degrees of fibrosis and a paucity of fat, mimicking desmoid fibromatosis and other fibrotic soft tissue tumors. Thus, it is important for radiologists to be aware of the subtypes of liposarcoma and their unique characteristics, and to consider sclerosing WDL/ALT in cases of fibrotic soft tissue tumors.
Identifiants
pubmed: 38819449
doi: 10.1007/s00256-024-04716-1
pii: 10.1007/s00256-024-04716-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to International Skeletal Society (ISS).
Références
Kim T, Murakami T, Oi H, Tsuda K, Matsushita M, Tomoda K, et al. CT and MR imaging of abdominal liposarcoma. AJR Am J Roentgenol. 1996;166(4):829–33.
doi: 10.2214/ajr.166.4.8610559
pubmed: 8610559
Bestic JM, Kransdorf MJ, White LM, Bridges MD, Murphey MD, Peterson JJ, et al. Sclerosing variant of well-differentiated liposarcoma: relative prevalence and spectrum of CT and MRI features. AJR Am J Roentgenol. 2013;201(1):154–61.
doi: 10.2214/AJR.12.9462
pubmed: 23789670
Bansal A, Goyal S, Goyal A, Jana M. WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists. Eur J Radiol. 2021;143:109937.
doi: 10.1016/j.ejrad.2021.109937
pubmed: 34547634
Burke CJ, Fritz J, Samim M. Musculoskeletal soft-tissue masses: MR imaging-ultrasonography correlation, with an emphasis on the 2020 World Health Organization Classification. Magn Reson Imaging Clin N Am. 2023;31(2):285–308.
doi: 10.1016/j.mric.2022.10.001
pubmed: 37019551
Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol. 1995;164(1):129–34.
doi: 10.2214/ajr.164.1.7998525
pubmed: 7998525
Weiss SW, Goldblum JR. Liposarcoma. In: Weiss SW, Goldblum JR, Folpe AL, editors. Enzinger and Weiss's soft tissue tumors. 5th ed. Philadelphia, PA: Mosby Elsevier; 2008.
Dei Tos AP, Pedeutour F. Atypical lipomatous tumour/well differentiated liposarcoma. In: Fletcher CD, Unni K, Mertens F, editors. World Health Organization classification of tumours Pathology and genetics of tumours of soft tissue and bone. Lyon, France: IARC press; 2002. p. 35–7.
Suster S, Morrison C. Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Histopathology. 2008;52(3):283–93.
doi: 10.1111/j.1365-2559.2007.02936.x
pubmed: 18269578
Weiss SW, Rao VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of “dedifferentiation”. Am J Surg Pathol. 1992;16(11):1051–8.
doi: 10.1097/00000478-199211000-00003
pubmed: 1471725
Rauh J, Klein A, Baur-Melnyk A, Knösel T, Lindner L, Roeder F, et al. The role of surgical margins in atypical lipomatous tumours of the extremities. BMC Musculoskelet Disord. 2018;19(1):152.
doi: 10.1186/s12891-018-2053-3
pubmed: 29776450
pmcid: 5960141
Chrisinger JSA, Al-Zaid T, Keung EZ, Leung C, Lin HY, Roland CL, et al. The degree of sclerosis is associated with prognosis in well-differentiated liposarcoma of the retroperitoneum. J Surg Oncol. 2019;120(3):382–8.
doi: 10.1002/jso.25585
pubmed: 31206726
pmcid: 7652035
Sciot R. MDM2 Amplified sarcomas: a literature review. Diagnostics (Basel). 2021;11(3)
Egan JB, Barrett MT, Champion MD, Middha S, Lenkiewicz E, Evers L, et al. Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. PLoS One. 2014;9(2):e87113.
doi: 10.1371/journal.pone.0087113
pubmed: 24505276
pmcid: 3914808
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. Cell. 2017;171(4):950–65.e28.
Laurino L, Furlanetto A, Orvieto E, Dei Tos AP. Well-differentiated liposarcoma (atypical lipomatous tumors). Semin Diagn Pathol. 2001;18(4):258–62.
pubmed: 11757865
Ahlawat S, Fayad LM. Revisiting the WHO classification system of soft tissue tumours: emphasis on advanced magnetic resonance imaging sequences. Part 1. Pol J Radiol. 2020;85:e396–408.
doi: 10.5114/pjr.2020.98685
pubmed: 32999693
pmcid: 7509695
Murphey MD, Arcara LK, Fanburg-Smith J. From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 2005;25(5):1371–95.
doi: 10.1148/rg.255055106
pubmed: 16160117
Hornick JL. Practical soft tissue pathology: a diagnostic approach. 2nd ed. Philadelphia, PA: Elsevier; 2019.
Lucas DR, Nascimento AG, Sanjay BK, Rock MG. Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases. Am J Clin Pathol. 1994;102(5):677–83.
doi: 10.1093/ajcp/102.5.677
pubmed: 7942636
Kooby DA, Antonescu CR, Brennan MF, Singer S. Atypical lipomatous tumor/well-differentiated liposarcoma of the extremity and trunk wall: importance of histological subtype with treatment recommendations. Ann Surg Oncol. 2004;11(1):78–84.
doi: 10.1007/BF02524350
pubmed: 14699038
Kilpatrick SE. Atypical lipomatous tumor/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated? Hum Pathol. 2023;
Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89.
doi: 10.1097/PAS.0b013e3180581fff
pubmed: 17895748
Aidid F, Aichouni N, Afilal I, Abbou W, Jabi R, Miry N, et al. Retroperitoneal desmoid tumor in a patient with familial adenomatous polyposis: a case report. Radiol Case Rep. 2022;17(9):2910–4.
doi: 10.1016/j.radcr.2022.05.013
pubmed: 35755096
pmcid: 9218292
Kasper B, Ströbel P, Hohenberger P. Desmoid tumors: clinical features and treatment options for advanced disease. Oncologist. 2011;16(5):682–93.
doi: 10.1634/theoncologist.2010-0281
pubmed: 21478276
pmcid: 3228186
Braschi-Amirfarzan M, Keraliya AR, Krajewski KM, Tirumani SH, Shinagare AB, Hornick JL, et al. Role of imaging in management of desmoid-type fibromatosis: a primer for radiologists. Radiographics. 2016;36(3):767–82.
doi: 10.1148/rg.2016150153
pubmed: 27163593
Otero S, Moskovic EC, Strauss DC, Benson C, Miah AB, Thway K, et al. Desmoid-type fibromatosis. Clin Radiol. 2015;70(9):1038–45.
doi: 10.1016/j.crad.2015.04.015
pubmed: 26162574
Cronin CG, Lohan DG, Blake MA, Roche C, McCarthy P, Murphy JM. Retroperitoneal fibrosis: a review of clinical features and imaging findings. AJR Am J Roentgenol. 2008;191(2):423–31.
doi: 10.2214/AJR.07.3629
pubmed: 18647912