Marital status after colorectal surgery in familial adenomatous polyposis: a nationwide multicenter study in Japan.

Adenocarcinoma Delivery Familial adenomatous polyposis Fecundity Fertility Quality of life Social disorder

Journal

International journal of clinical oncology
ISSN: 1437-7772
Titre abrégé: Int J Clin Oncol
Pays: Japan
ID NLM: 9616295

Informations de publication

Date de publication:
31 May 2024
Historique:
received: 04 02 2024
accepted: 17 05 2024
medline: 31 5 2024
pubmed: 31 5 2024
entrez: 31 5 2024
Statut: aheadofprint

Résumé

Patients with familial adenomatous polyposis (FAP) experience psychological and social challenges concerning future events such as marriage and childbirth alongside the medical risks of colorectal cancer (CRC) and FAP-related disease. We retrospectively investigated the rate of marriage and childbirth postoperatively in Japanese patients with FAP. We included 161 patients who had colorectal surgery and reported marital status from a national survey of 35 Japanese institutions. Participants were classified according to marital status: married before colectomy (80 patients), married after colectomy (13 patients), and unmarried (68 patients). The marriage rate for all 161 patients (57.8%, standardized ratio 0.95, 95% confidence interval [CI] 0.76-1.14) was comparable to that in the general Japanese population (57.1%). The marriage rate among the 81 patients who were unmarried before colectomy was low (16.0%); however, the standardized marital ratio (0.75, 95% CI 0.34-1.15) was not significantly lower than that of the general population. In multivariable logistic regression, younger age (born after 1980, odds ratio [OR] 0.12, p < 0.001) and genetic testing (OR 4.06, p = 0.001) were associated with postoperative marriage. Seventy-one percent of patients with FAP who married after colectomy became pregnant and achieved delivery. The marriage rate of patients with FAP was comparable to that of the general population whereas the rate after colectomy was low among patients with FAP. However, in patients with FAP, colorectal surgery itself may not lead to negative consequences in terms of fecundity.

Sections du résumé

BACKGROUND BACKGROUND
Patients with familial adenomatous polyposis (FAP) experience psychological and social challenges concerning future events such as marriage and childbirth alongside the medical risks of colorectal cancer (CRC) and FAP-related disease. We retrospectively investigated the rate of marriage and childbirth postoperatively in Japanese patients with FAP.
METHODS METHODS
We included 161 patients who had colorectal surgery and reported marital status from a national survey of 35 Japanese institutions. Participants were classified according to marital status: married before colectomy (80 patients), married after colectomy (13 patients), and unmarried (68 patients).
RESULTS RESULTS
The marriage rate for all 161 patients (57.8%, standardized ratio 0.95, 95% confidence interval [CI] 0.76-1.14) was comparable to that in the general Japanese population (57.1%). The marriage rate among the 81 patients who were unmarried before colectomy was low (16.0%); however, the standardized marital ratio (0.75, 95% CI 0.34-1.15) was not significantly lower than that of the general population. In multivariable logistic regression, younger age (born after 1980, odds ratio [OR] 0.12, p < 0.001) and genetic testing (OR 4.06, p = 0.001) were associated with postoperative marriage. Seventy-one percent of patients with FAP who married after colectomy became pregnant and achieved delivery.
CONCLUSIONS CONCLUSIONS
The marriage rate of patients with FAP was comparable to that of the general population whereas the rate after colectomy was low among patients with FAP. However, in patients with FAP, colorectal surgery itself may not lead to negative consequences in terms of fecundity.

Identifiants

DOI: 10.1007/s10147-024-02558-4 PMID: 38819608
pubmed: 38819608
doi: 10.1007/s10147-024-02558-4
pii: 10.1007/s10147-024-02558-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.

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Auteurs

Kenji Fujiyoshi (K)

Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan. fujiyoshi_kenji@med.kurume-u.ac.jp.
ORCID: 0000-0002-0310-5807

Tomoya Sudo (T)

Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.

Fumihiko Fujita (F)

Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Shinichi Tanihara (S)

Department of Public Health, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Hideyuki Ishida (H)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, 350-8550, Japan.

Satoki Shichijo (S)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Akiko Chino (A)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Gastroenterology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan.

Toshiya Nagasaski (T)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan.

Akinari Takao (A)

Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Kazuhito Sasaki (K)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Kiwamu Akagi (K)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, 818 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japan.

Takaaki Matsubara (T)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgery, Division of Lower Gastrointestinal Surgery, Hyogo College of Medicine, Nishinomiya, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.

Hideki Ueno (H)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Keiji Hirata (K)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgery I, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu-shi, Fukuoka, 807-8555, Japan.

Yasuyuki Miyakura (Y)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgery, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-0834, Japan.

Toshiaki Ishikawa (T)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Clinical Oncology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Eiji Sunami (E)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-0004, Japan.

Yusuke Takahashi (Y)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgery, National Hospital Organization Osaka National Hospital, 2-1-1 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan.

Tatsuro Yamaguchi (T)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Kohji Tanakaya (K)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Department of Surgery, Iwakuni Clinical Center, 1-1-1 Atago-cho, Iwakuni-shi, Yamaguchi, 740-8510, Japan.

Naohiro Tomita (N)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Cancer Treatment Center, Toyonaka Municipal Hospital, 4-14-1 Shibahara-cho, Toyonaka-shi, Osaka, 560-8565, Japan.

Yoichi Ajioka (Y)

Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum, Sanbancho KS Building, 2 Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan.
Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibancho, Asahimachi-dori, Chuo Ward, Niigata, 951-8510, Japan.

Classifications MeSH