Molecular Pathology of Gastroesophageal Cancer.

Humans Esophageal Neoplasms / pathology Stomach Neoplasms / pathology Adenocarcinoma / pathology Carcinoma, Squamous Cell / pathology Pathology, Molecular
Esophageal adenocarcinoma Esophageal squamous cell carcinoma Gastric adenocarcinoma Molecular pathology

Journal

Clinics in laboratory medicine
ISSN: 1557-9832
Titre abrégé: Clin Lab Med
Pays: United States
ID NLM: 8100174

Informations de publication

Date de publication:
Jun 2024
Historique:
medline: 1 6 2024
pubmed: 1 6 2024
entrez: 31 5 2024
Statut: ppublish

Résumé

Upper gastroesophageal carcinomas consist of cancers arising from the esophagus and stomach. Squamous cell carcinomas and adenocarcinomas are seen in the esophagus and despite arising from the same organ have different biology. Gastric adenocarcinomas are categorized into 4 molecular subtypes: high Epstein-Barr virus load, microsatellite unstable cancers, chromosomal unstable (CIN) cancers, and genomically stable cancers. Genomically stable gastric cancers correlate highly with histologically defined diffuse-type cancers. Esophageal carcinomas and CIN gastric cancers often are driven by high-level amplifications of oncogenes and contain a high degree of intratumoral heterogeneity. Targeted therapeutics is an active area of research for gastroesophageal cancers.

Identifiants

DOI: 10.1016/j.cll.2023.08.005 PMID: 38821643
pubmed: 38821643
pii: S0272-2712(23)00082-3
doi: 10.1016/j.cll.2023.08.005
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

239-254

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Matthew D Stachler (MD)

Department of Pathology, University of California San Francisco, 513 Parnassus Avenue HSW450B, San Francisco, CA 94143, USA. Electronic address: Matthew.Stachler@UCSF.edu.

Ramon U Jin (RU)

Section of Hematology/Oncology, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Suite 7B, MS: BCM904, Houston, TX 77030, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular Pathology of Gastroesophageal Cancer.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Tumeurs gastro-intestinales › Tumeurs de l'oesophage › Molecular Pathology of Gastroesophageal Cancer.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Molecular Pathology of Gastroesophageal Cancer.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Molecular Pathology of Gastroesophageal Cancer.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Molecular Pathology of Gastroesophageal Cancer.
questionsmedicales.fr › Professions de santé › Médecine › Anatomopathologie › Anatomopathologie moléculaire › Molecular Pathology of Gastroesophageal Cancer.