Deep brain stimulation of symptom-specific networks in Parkinson's disease.

Humans Deep Brain Stimulation / methods Parkinson Disease / therapy Male Female Middle Aged Aged Tremor / therapy Motor Cortex / physiopathology Algorithms Hypokinesia / therapy White Matter / pathology Muscle Rigidity / therapy Cerebellum / physiopathology Cohort Studies Treatment Outcome

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
31 May 2024
Historique:
received: 14 03 2023
accepted: 13 05 2024
medline: 1 6 2024
pubmed: 1 6 2024
entrez: 31 5 2024
Statut: epublish

Résumé

Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson's disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a large cohort of patients (N = 237 from five centers) to identify tracts associated with improvements in each of the four symptom domains. Tremor improvements were associated with stimulation of tracts connected to primary motor cortex and cerebellum. In contrast, axial symptoms are associated with stimulation of tracts connected to the supplementary motor cortex and brainstem. Bradykinesia and rigidity improvements are associated with the stimulation of tracts connected to the supplementary motor and premotor cortices, respectively. We introduce an algorithm that uses these symptom-response tracts to suggest optimal stimulation parameters for DBS based on individual patient's symptom profiles. Application of the algorithm illustrates that our symptom-tract library may bear potential in personalizing stimulation treatment based on the symptoms that are most burdensome in an individual patient.

Identifiants

DOI: 10.1038/s41467-024-48731-1 PMID: 38821913
pubmed: 38821913
doi: 10.1038/s41467-024-48731-1
pii: 10.1038/s41467-024-48731-1
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

4662

Subventions

Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 424778381 - TRR 295

Informations de copyright

© 2024. The Author(s).

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Auteurs

Nanditha Rajamani (N)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. nrajamani@bwh.harvard.edu.
ORCID: 0000-0002-2511-9839

Helen Friedrich (H)

Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
University of Würzburg, Faculty of Medicine, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.

Konstantin Butenko (K)

Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-4509-4624

Till Dembek (T)

Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, University of Cologne, Cologne, Germany.

Florian Lange (F)

Department of Neurology, University Clinic of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Pavel Navrátil (P)

Department of Neurology, University Clinic of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Patricia Zvarova (P)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Einstein Center Digital Future, Berlin, 10117, Germany.

Barbara Hollunder (B)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Einstein Center Digital Future, Berlin, 10117, Germany.
Brain Simulation Section, Department of Neurology, Charité University Medicine Berlin and Berlin Institute of Health, Berlin, 10117, Germany.
ORCID: 0000-0003-0104-6927

Rob M A de Bie (RMA)

Department of Neurology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Vincent J J Odekerken (VJJ)

Department of Neurology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Jens Volkmann (J)

Department of Neurology, University Clinic of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Xin Xu (X)

Department of Neurosurgery, Chinese PLA General Hospital, Beijing, 100853, China.

Zhipei Ling (Z)

Department of Neurosurgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan, 572000, China.

Chen Yao (C)

Department of Neurosurgery, The National Key Clinic Specialty, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.

Petra Ritter (P)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Einstein Center Digital Future, Berlin, 10117, Germany.
Brain Simulation Section, Department of Neurology, Charité University Medicine Berlin and Berlin Institute of Health, Berlin, 10117, Germany.
Bernstein center for Computational Neuroscience Berlin, Berlin, 10117, Germany.
ORCID: 0000-0002-4643-4782

Wolf-Julian Neumann (WJ)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Georgios P Skandalakis (GP)

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.
Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.

Spyridon Komaitis (S)

Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.
Centre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Aristotelis Kalyvas (A)

Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.
Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Christos Koutsarnakis (C)

Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.

George Stranjalis (G)

Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital, Athens, Greece.

Michael Barbe (M)

Department of Neurology, University of Cologne, Cologne, Germany.

Vanessa Milanese (V)

Neurosurgical Division, Hospital Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
Department of Neurosurgery, Mayo Clinic, Florida, USA.
Movement Disorders and Neuromodulation Unit, DOMMO Clinic, São Paulo, Brazil.

Michael D Fox (MD)

Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, 02114, USA.
Brain Modulation Lab, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
ORCID: 0000-0001-8848-6399

Andrea A Kühn (AA)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Einstein Center Digital Future, Berlin, 10117, Germany.
Brain Simulation Section, Department of Neurology, Charité University Medicine Berlin and Berlin Institute of Health, Berlin, 10117, Germany.
ORCID: 0000-0002-4134-9060

Erik Middlebrooks (E)

Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, USA.

Ningfei Li (N)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
ORCID: 0000-0003-3315-3591

Martin Reich (M)

Department of Neurology, University Clinic of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.
ORCID: 0000-0001-9115-5136

Clemens Neudorfer (C)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, 02114, USA.
Brain Modulation Lab, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.

Andreas Horn (A)

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, 02114, USA.
Brain Modulation Lab, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
ORCID: 0000-0002-0695-6025

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1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

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