An ethologically relevant paradigm to assess defensive response to looming visual contrast stimuli.
Animals
Rats
Mice
Male
Retinal Ganglion Cells
/ physiology
Photic Stimulation
Female
Contrast Sensitivity
/ physiology
Behavior, Animal
/ physiology
Retinal Cone Photoreceptor Cells
/ physiology
Mice, Inbred C57BL
Visual Perception
/ physiology
Fear
/ physiology
Retina
/ physiology
Visual Pathways
/ physiology
Contrast sensitivity
Contrast-dependent behavior
Looming test in rodents
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 May 2024
31 May 2024
Historique:
received:
04
03
2024
accepted:
29
05
2024
medline:
1
6
2024
pubmed:
1
6
2024
entrez:
31
5
2024
Statut:
epublish
Résumé
In the animal kingdom, threat information is perceived mainly through vision. The subcortical visual pathway plays a critical role in the rapid processing of visual information-induced fear, and triggers a response. Looming-evoked behavior in rodents, mimicking response to aerial predators, allowed identify the neural circuitry underlying instinctive defensive behaviors; however, the influence of disk/background contrast on the looming-induced behavioral response has not been examined, either in rats or mice. We studied the influence of the dark disk/gray background contrast in the type of rat and mouse defensive behavior in the looming arena, and we showed that rat and mouse response as a function of disk/background contrast adjusted to a sigmoid-like relationship. Both sex and age biased the contrast-dependent response, which was dampened in rats submitted to retinal unilateral or bilateral ischemia. Moreover, using genetically manipulated mice, we showed that the three type of photoresponsive retinal cells (i.e., cones, rods, and intrinsically photoresponsive retinal ganglion cells (ipRGCs)), participate in the contrast-dependent response, following this hierarchy: cones > > rods > > > ipRGCs. The cone and rod involvement was confirmed using a mouse model of unilateral non-exudative age-related macular degeneration, which only damages canonical photoreceptors and significantly decreased the contrast sensitivity in the looming arena.
Identifiants
pubmed: 38822033
doi: 10.1038/s41598-024-63458-1
pii: 10.1038/s41598-024-63458-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12499Subventions
Organisme : National Institute of Health, United States
ID : DP2 EY022584 ; R01 EY030565
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT 0415, PICT 0157, PICT 1506
Organisme : Consejo Nacional de Investigaciones Científicas y Técnicas
ID : PIP 12320220100606CO
Organisme : Universidad de Buenos Aires
ID : 20020220100070BA
Informations de copyright
© 2024. The Author(s).
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