Role of bacterial multidrug efflux pumps during infection.
Antibiotic resistance
Bacterial virulence
Host-microbe interactions
Infection
Multidrug efflux pumps
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
01 Jun 2024
01 Jun 2024
Historique:
received:
03
04
2024
accepted:
29
05
2024
medline:
1
6
2024
pubmed:
1
6
2024
entrez:
31
5
2024
Statut:
epublish
Résumé
Multidrug efflux pumps are protein complexes located in the cell envelope that enable bacteria to expel, not only antibiotics, but also a wide array of molecules relevant for infection. Hence, they are important players in microbial pathogenesis. On the one hand, efflux pumps can extrude exogenous compounds, including host-produced antimicrobial molecules. Through this extrusion, pathogens can resist antimicrobial agents and evade host defenses. On the other hand, efflux pumps also have a role in the extrusion of endogenous compounds, such as bacterial intercommunication signaling molecules, virulence factors or metabolites. Therefore, efflux pumps are involved in the modulation of bacterial behavior and virulence, as well as in the maintenance of the bacterial homeostasis under different stresses found within the host. This review delves into the multifaceted roles that efflux pumps have, shedding light on their impact on bacterial virulence and their contribution to bacterial infection. These observations suggest that strategies targeting bacterial efflux pumps could both reinvigorate the efficacy of existing antibiotics and modulate the bacterial pathogenicity to the host. Thus, a comprehensive understanding of bacterial efflux pumps can be pivotal for the development of new effective strategies for the management of infectious diseases.
Identifiants
pubmed: 38822187
doi: 10.1007/s11274-024-04042-7
pii: 10.1007/s11274-024-04042-7
doi:
Substances chimiques
Anti-Bacterial Agents
0
Membrane Transport Proteins
0
Bacterial Proteins
0
Virulence Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
226Subventions
Organisme : The Novo Nordisk Foundation (NNF)
ID : NNF19OC0056411
Organisme : Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación (MCIN/AEI)
ID : PID2020-113521RB-I00
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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