Prospective Effects of Self-Rated Health on Dementia Risk in Two Twin Studies of Aging.
Dementia risk
Genetic risk
Self-rated health
Subjective health
Twins
Journal
Behavior genetics
ISSN: 1573-3297
Titre abrégé: Behav Genet
Pays: United States
ID NLM: 0251711
Informations de publication
Date de publication:
01 Jun 2024
01 Jun 2024
Historique:
received:
16
05
2023
accepted:
13
04
2024
medline:
1
6
2024
pubmed:
1
6
2024
entrez:
31
5
2024
Statut:
aheadofprint
Résumé
Subjective health ratings are associated with dementia risk such that those who rate their health more poorly have increased risk for dementia. The genetic and environmental mechanisms underlying this association are unclear, as prior research cannot rule out whether the association is due to genetic confounds. The current study addresses this gap in two samples of twins, one from Sweden (N = 548) and one from Denmark (N = 4,373). Using genetically-informed, bivariate regression models, we assessed whether additive genetic effects explained the association between subjective health and dementia risk as indexed by a latent variable proxy measure. Age at intake, sex, education, depressive symptomatology, and follow-up time between subjective health and dementia risk assessments were included as covariates. Results indicate that genetic variance and other sources of confounding accounted for the majority of the effect of subjective health ratings on dementia risk. After adjusting for genetic confounding and other covariates, a small correlation was observed between subjective health and latent dementia risk in the Danish sample (r
Identifiants
pubmed: 38822218
doi: 10.1007/s10519-024-10182-1
pii: 10.1007/s10519-024-10182-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01AG060470
Pays : United States
Organisme : Alzheimer's Association
ID : AARF-17-505302
Pays : United States
Informations de copyright
© 2024. The Author(s).
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