Relationship of apolipoprotein C-III proteoform composition with ankle-brachial index and peripheral artery disease in the Multi-Ethnic Study of Atherosclerosis (MESA).

Ankle-brachial index Apolipoproteins Lipids Peripheral artery disease Posttranslational proteoforms

Journal

Atherosclerosis
ISSN: 1879-1484
Titre abrégé: Atherosclerosis
Pays: Ireland
ID NLM: 0242543

Informations de publication

Date de publication:
16 May 2024
Historique:
received: 12 01 2024
revised: 06 05 2024
accepted: 14 05 2024
medline: 2 6 2024
pubmed: 2 6 2024
entrez: 1 6 2024
Statut: aheadofprint

Résumé

Apolipoprotein C-III (apoC-III) proteoform composition shows distinct relationships with plasma lipids and cardiovascular risk. The present study tested whether apoC-III proteoforms are associated with risk of peripheral artery disease (PAD). ApoC-III proteoforms, i.e., native (C-III Higher baseline C-III We found associations of apoC-III proteoform composition with changes in ABI that were independent of other risk factors, including plasma lipids. Our data further support unique properties of apoC-III proteoforms in modulating vascular health that go beyond total apoC-III levels.

Sections du résumé

BACKGROUND AND AIMS OBJECTIVE
Apolipoprotein C-III (apoC-III) proteoform composition shows distinct relationships with plasma lipids and cardiovascular risk. The present study tested whether apoC-III proteoforms are associated with risk of peripheral artery disease (PAD).
METHODS METHODS
ApoC-III proteoforms, i.e., native (C-III
RESULTS RESULTS
Higher baseline C-III
CONCLUSIONS CONCLUSIONS
We found associations of apoC-III proteoform composition with changes in ABI that were independent of other risk factors, including plasma lipids. Our data further support unique properties of apoC-III proteoforms in modulating vascular health that go beyond total apoC-III levels.

Identifiants

DOI: 10.1016/j.atherosclerosis.2024.117584 PMID: 38823352
pubmed: 38823352
pii: S0021-9150(24)00144-8
doi: 10.1016/j.atherosclerosis.2024.117584
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

117584

Informations de copyright

Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Juraj Koska (J)

Phoenix VA Health Care System, 650 E Indian School Rd CS111E, Phoenix, AZ, 85012, USA. Electronic address: juraj.koska@va.gov.

Spencer Hansen (S)

Department of Biostatistics, University of Washington, 6200 NE 74th St. Bldg. 29 Suite 210, Seattle, WA, 98115, USA.

Yueming Hu (Y)

Isoformix Inc., 202 Industrial Blvd Suite 404, Sugar Land, TX, 77478, USA.

Majken C Jensen (MC)

Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA; Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1353, Copenhagen, Denmark.

Dean Billheimer (D)

Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin Ave, Tucson, AZ, 85724, USA.

Dobrin Nedelkov (D)

Isoformix Inc., 202 Industrial Blvd Suite 404, Sugar Land, TX, 77478, USA.

Matthew J Budoff (MJ)

Lundquist Institute at Harbor-University of California, Los Angeles (UCLA), 1124 W Carson St., Torrance, CA, 90502, USA.

Matthew Allison (M)

Department of Family Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

Robyn L McClelland (RL)

Department of Biostatistics, University of Washington, 6200 NE 74th St. Bldg. 29 Suite 210, Seattle, WA, 98115, USA.

Peter D Reaven (PD)

Phoenix VA Health Care System, 650 E Indian School Rd CS111E, Phoenix, AZ, 85012, USA.

Classifications MeSH