Suppression of neointimal hyperplasia induced by arteriovenous anastomosis and balloon injury in rats by multimeric tumor necrosis factor-related apoptosis-inducing factor.

Excessive blood vessel wall thickening, known as intimal hyperplasia, can result from injury or inflammation and increase the risk of vascular diseases. Tumor necrosis factor-related apoptosis-inducing factor (TRAIL) plays key roles in tumor surveillance, autoimmune diseases, and apoptosis; however, its role in vascular stenosis remains controversial. Treatment with recombinant isoleucine zipper hexamerization domain soluble TRAIL (ILz(6):TRAIL) significantly inhibited the progression of neointimal hyperplasia (NH) induced by anastomosis of the carotid artery and jugular vein (AAV) dose dependently, and adenovirus expressing secretable ILz(6):TRAIL also inhibited NH induced by balloon injury in the femoral artery of rats. This study demonstrated the preventive and partial regressive effects of ILz(6):TRAIL on AAV- or balloon-induced NH.

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Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following interests: Authors Ji Hye Han, Sun-Young Park, Seung-Hyun Myung, and Junghee Park were employed by Professor Tae-Hyoung Kim and actively contributed to the experimental design, execution, and analysis of the research presented in this paper. Dr. Jeong Hwan Chang, a Vascular Surgeon, contributed to the study's conceptualization and assisted in the design and interpretation of the research. Corresponding Author Professor Tae-Hyoung Kim, affiliated with Chosun University, received institutional support from Chosun University in 2021, facilitating the development of this manuscript. All authors report no additional conflicts of interest related to this work. Conflict of Interest No conflict of interest.