Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants.

Humans Desmin / metabolism Peripheral Arterial Disease / metabolism Male Female Muscle, Skeletal / metabolism Aged Middle Aged Intermittent Claudication / surgery Walking Hemodynamics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
01 Jun 2024
Historique:
received: 11 01 2024
accepted: 30 05 2024
medline: 2 6 2024
pubmed: 2 6 2024
entrez: 1 6 2024
Statut: epublish

Résumé

Peripheral artery disease (PAD) is characterized by varying severity of arterial stenosis, exercise induced claudication, malperfused tissue precluding normal healing and skeletal muscle dysfunction. Revascularization interventions improve circulation, but post-reperfusion changes within the skeletal muscle are not well characterized. This study investigates if revascularization enhanced hemodynamics increases walking performance with concurrent improvement of mitochondrial function and reverses abnormal skeletal muscle morphological features that develop with PAD. Fifty-eight patients completed walking performance testing and muscle biopsy before and 6 months after revascularization procedures. Muscle fiber morphology, desmin structure, and mitochondria respiration assessments before and after the revascularization were evaluated. Revascularization improved limb hemodynamics, walking function, and muscle morphology. Qualitatively not all participants recovered normal structural architecture of desmin in the myopathic myofibers after revascularization. Heterogenous responses in the recovery of desmin structure following revascularization may be caused by other underlying factors not reversed with hemodynamic improvements. Revascularization interventions clinically improve patient walking ability and can reverse the multiple subcellular functional and structural abnormalities in muscle cells. Further study is needed to characterize desmin structural remodeling with improvements in skeletal muscle morphology and function.

Identifiants

DOI: 10.1038/s41598-024-63626-3 PMID: 38824194
pubmed: 38824194
doi: 10.1038/s41598-024-63626-3
pii: 10.1038/s41598-024-63626-3
doi:

Substances chimiques

Desmin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

12609

Subventions

Organisme : NIA NIH HHS
ID : R01AG064420
Pays : United States

Informations de copyright

© 2024. The Author(s).

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Auteurs

Dylan Wilburn (D)

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX, 76798-7388, USA.

Dimitrios Miserlis (D)

Department of Surgery and Perioperative Care, University of Texas, Austin, TX, USA.
Department of Surgery, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.

Emma Fletcher (E)

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX, 76798-7388, USA.

Evlampia Papoutsi (E)

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX, 76798-7388, USA.

Ahmed Ismaeel (A)

Department of Physiology, University of Kentucky, Lexington, KY, USA.

Cassandra Bradley (C)

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX, 76798-7388, USA.

Andrew Ring (A)

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX, 76798-7388, USA.

Trevor Wilkinson (T)

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX, 76798-7388, USA.

Robert S Smith (RS)

Department of Surgery, Baylor Scott & White Medical Center, Temple, TX, USA.

Lucas Ferrer (L)

Department of Surgery and Perioperative Care, University of Texas, Austin, TX, USA.

Gleb Haynatzki (G)

Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.

Peter Monteleone (P)

Department of Internal Medicine, University of Texas, Austin, TX, USA.

Subhash Banerjee (S)

Department of Cardiology, Baylor Scott & White Medical Center, Dallas, TX, USA.

Elizabeth Brisbois (E)

School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, USA.

William T Bohannon (WT)

Department of Surgery, Baylor Scott & White Medical Center, Temple, TX, USA.

Panagiotis Koutakis (P)

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX, 76798-7388, USA. panagiotis_koutakis@baylor.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Skeletal muscle desmin alterations following...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Desmine › Skeletal muscle desmin alterations following...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Maladies vasculaires périphériques › Maladie artérielle périphérique › Skeletal muscle desmin alterations following...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Skeletal muscle desmin alterations following...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Skeletal muscle desmin alterations following...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Skeletal muscle desmin alterations following...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Claudication intermittente › Skeletal muscle desmin alterations following...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Marche à pied › Skeletal muscle desmin alterations following...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Skeletal muscle desmin alterations following...