Increased alcohol intake is associated with radiographic severity of knee and hand osteoarthritis in men.
Humans
Male
Alcohol Drinking
/ adverse effects
Female
Middle Aged
Osteoarthritis, Knee
/ diagnostic imaging
Aldehyde Dehydrogenase, Mitochondrial
/ genetics
Osteoarthritis
/ genetics
Aged
Radiography
Severity of Illness Index
Hand Joints
/ diagnostic imaging
Genotype
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Knee Joint
/ diagnostic imaging
Alcohol
Hand
Knee
Osteoarthritis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 06 2024
02 06 2024
Historique:
received:
13
01
2024
accepted:
30
05
2024
medline:
3
6
2024
pubmed:
3
6
2024
entrez:
2
6
2024
Statut:
epublish
Résumé
Observational studies have shown controversial associations between alcohol intake and radiographic osteoarthritis (OA). This study investigated whether this association was causal using a Mendelian randomization (MR) study in a population-based cohort in Korean. The study enrolled 2429 subjects (1058 men, 1371 women) from the Dong-gu Study. X-rays of the hand and knee joints were scored using a semi-quantitative grading system to calculate the total score of the hand and knee joints. ALDH2 rs671 genotyping was performed by high-resolution melting analysis. MR instrumental variable analysis and observational multivariable regression analysis were used to estimate the association between genetically predicted alcohol intake and the radiographic severity of OA. Subjects with the G/G genotype had a higher current alcohol intake than those with the G/A and A/A genotypes in both men and women (all P < 0.001). Men with the G/G genotype had higher total knee (P < 0.001) and hand scores (P = 0.042) compared to those with the G/A and A/A genotypes after adjusting for age and body mass index, but not in women. In the observational multivariable regression analysis, each alcohol drink per day in men was associated with increased knee (P = 0.001) and hand joint scores (P = 0.013) after adjustment, but not in women. In our MR analysis, utilizing ALDH2 rs671 genotypes as instrumental variables for alcohol consumption, has shown a significant link between each additional daily alcohol drink and increased radiographic joint severity in men.
Identifiants
pubmed: 38825629
doi: 10.1038/s41598-024-63559-x
pii: 10.1038/s41598-024-63559-x
doi:
Substances chimiques
Aldehyde Dehydrogenase, Mitochondrial
EC 1.2.1.3
ALDH2 protein, human
EC 1.2.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12648Subventions
Organisme : Chonnam National University Hospital Biomedical Research Institute
ID : BCRI22024
Informations de copyright
© 2024. The Author(s).
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