Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) in a 25-Year-Old Patient: A Case Report.

cadasil cognitive decline hereditary ischemic events notch3 gene psychiatric symptoms

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
May 2024
Historique:
accepted: 02 05 2024
medline: 3 6 2024
pubmed: 3 6 2024
entrez: 3 6 2024
Statut: epublish

Résumé

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare genetic disorder caused by mutations in the NOTCH3 gene, resulting in subcortical infarctions and leukoencephalopathy. It predominantly affects the brain's small blood arteries, resulting in repeated ischemic episodes including transient ischemic attacks and strokes leading to cognitive impairment and mental symptoms. We provide a case study of a 25-year-old patient suspected of having meningoencephalitis. CADASIL was diagnosed based on clinical examination, imaging investigations, and genetic analysis. Optimal patient care for this complicated illness requires early detection and proper management.

Identifiants

pubmed: 38826931
doi: 10.7759/cureus.59550
pmc: PMC11144273
doi:

Types de publication

Case Reports

Langues

eng

Pagination

e59550

Informations de copyright

Copyright © 2024, Ullah et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Auteurs

Zahid Ullah (Z)

General Medicine, Khyber Teaching Hospital, Peshawar, PAK.

Ebad-Ur Rehman Syed (ER)

Internal Medicine, Royal College of Surgeons in Ireland, Busaiteen, BHR.

Noman Salih (N)

Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

Yamna Ali (Y)

Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

Abdul Wahab (A)

Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

Hidayat Ullah (H)

Medical C Unit, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

Classifications MeSH