Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity.

NO inhibitory activity Tribulus terrestris Zygophyllaceae furostanol glycoside tribufurostanosides A-E

Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
03 Jun 2024
Historique:
revised: 01 06 2024
received: 21 05 2024
accepted: 03 06 2024
medline: 3 6 2024
pubmed: 3 6 2024
entrez: 3 6 2024
Statut: aheadofprint

Résumé

Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A-E (1-5), and three known ones (6-8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1-8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 14.2 to 64.7 µM, compared to that of the positive control compound, dexamethazone (IC50 13.6 µM).

Identifiants

DOI: 10.1002/cbdv.202401273 PMID: 38828879
pubmed: 38828879
doi: 10.1002/cbdv.202401273
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202401273

Informations de copyright

© 2024 Wiley‐VCH GmbH.

Auteurs

Phan Van Kiem (PV)

Vietnam Academy of Science and Technology, Department of Structural Research, 18 Hoang Quoc Viet, 10000, Hanoi, VIET NAM.

Nguyen Van Quoc (N)

Vinh University, school of chemistry, biology and environment, Vinh, Vinh, Vinh, VIET NAM.

Bui Huu Tai (BH)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam, Hanoi, 84, Hanoi, VIET NAM.

Pham Hai Yen (PH)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Nguyen Huy Hoang (NH)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Dan Thi Thuy Hang (DTT)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Phan Thi Thanh Huong (PTT)

Vietnamese Academy of Science and Technology, Institute of Chemistry, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Hanoi, Hanoi, 10072, Hanoi, VIET NAM.

Ngo Anh Bang (NA)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Duong Thi Dung (DT)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Cau Giay,, Hanoi, Hanoi, VIET NAM.

Do Thi Trang (DT)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Le Duc Giang (LD)

Vinh University, Faculty of Chemistry, Vinh, Vinh, Vinh, VIET NAM.

Classifications MeSH