Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO


Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
03 Jun 2024
Historique:
medline: 3 6 2024
pubmed: 3 6 2024
entrez: 3 6 2024
Statut: epublish

Résumé

Connexins allow intercellular communication by forming gap junction channels (GJCs) between juxtaposed cells. Connexin26 (Cx26) can be regulated directly by CO

Identifiants

pubmed: 38829031
doi: 10.7554/eLife.93686
pii: 93686
doi:
pii:

Substances chimiques

Connexin 26 127120-53-0
Carbon Dioxide 142M471B3J
GJB2 protein, human 0
Connexins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Leverhulme Trust
ID : RPG-2015-090
Organisme : Medical Research Council
ID : MR/P010393/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17136
Pays : United Kingdom

Informations de copyright

© 2024, Brotherton et al.

Déclaration de conflit d'intérêts

DB, SN, CS, ND, AC No competing interests declared

Auteurs

Deborah H Brotherton (DH)

School of Life Sciences, University of Warwick, Coventry, United Kingdom.

Sarbjit Nijjar (S)

School of Life Sciences, University of Warwick, Coventry, United Kingdom.

Christos G Savva (CG)

Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.

Nicholas Dale (N)

School of Life Sciences, University of Warwick, Coventry, United Kingdom.

Alexander David Cameron (AD)

School of Life Sciences, University of Warwick, Coventry, United Kingdom.

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Classifications MeSH