Is there a best choice of equipment for colorectal endoscopic submucosal dissection?

Endoscopic submucosal dissection (ESD) is a widely used technique to remove early neoplastic lesions. It was primarily used in the initial days to treat gastric lesions, but recently, the horizon of this endoscopic procedure has expanded, that has allowed us to manage other technically more complex locations, such as the colorectum. There has been an exponential growth regarding the wide range of devices available in the market for performing colorectal ESD. As a result, the aim of the review is to highlight the indication of this endoscopic technique, which device is best suited for which indication, as well as future trajectories in this field. Although some devices have proven to be more advantageous than others in this area, very often the choice is still subjective, which is commonly attributed to individual preferences and experience. However, an accurate knowledge of the available tools and their functioning, with their pros and cons, is fundamental for any endoscopist venturing into the field of third space endoscopy. In this way, one can choose which device best suits a particular situation, along with simultaneously having the wealth of knowledge related to therapeutic armamentarium at our disposal in the endoscopy suite.