Metabolic Plasticity of Regulatory T Cells in Health and Autoimmunity.

T-Lymphocytes, Regulatory / immunology Humans Autoimmunity / immunology Animals Homeostasis / immunology Immune Tolerance / immunology Autoimmune Diseases / immunology Cell Differentiation / immunology Cell Plasticity / immunology

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 Jun 2024
Historique:
received: 09 02 2024
accepted: 05 04 2024
medline: 3 6 2024
pubmed: 3 6 2024
entrez: 3 6 2024
Statut: ppublish

Résumé

Immunometabolism has been demonstrated to control immune tolerance and the pathogenic events leading to autoimmunity. Compelling experimental evidence also suggests that intracellular metabolic programs influence differentiation, phenotype, proliferation, and effector functions of anti-inflammatory CD4+CD25+Foxp3+ regulatory T (Treg) cells. Indeed, alterations in intracellular metabolism associate with quantitative and qualitative impairments of Treg cells in several pathological conditions. In this review, we summarize the most recent advances linking how metabolic pathways control Treg cell homeostasis and their alterations occurring in autoimmunity. Also, we analyze how metabolic manipulations could be employed to restore Treg cell frequency and function with the aim to create novel therapeutic opportunities to halt immune-mediated disorders.

Identifiants

DOI: 10.4049/jimmunol.2400079 PMID: 38830147
pubmed: 38830147
pii: 266910
doi: 10.4049/jimmunol.2400079
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1859-1866

Subventions

Organisme : Ministero dell''''Istruzione, dell''''Università e della Ricerca (MIUR)
ID : 2022LNHZAP
Organisme : Ministero dell''''Istruzione, dell''''Università e della Ricerca (MIUR)
ID : PE00000007
Organisme : Ministero dell''''Istruzione, dell''''Università e della Ricerca (MIUR)
ID : PE00000006
Organisme : Italy Ministry of Health | Agenzia Italiana del Farmaco, Ministero della Salute (AIFA)
ID : RF-2019-12371111
Organisme : Italy Ministry of Health | Agenzia Italiana del Farmaco, Ministero della Salute (AIFA)
ID : PNRR-MAD-2022-12375634
Organisme : Italy Ministry of Health | Agenzia Italiana del Farmaco, Ministero della Salute (AIFA)
ID : GR-2018-12366154
Organisme : Fondazione Italiana Sclerosi Multipla (FISM)
ID : 2022-PRsingle/013
Organisme : Ministero dell''''Istruzione, dell''''Università e della Ricerca (MIUR)
ID : P2022T4PKT
Organisme : Italy Ministry of Health | Agenzia Italiana del Farmaco, Ministero della Salute (AIFA)
ID : PNRR-MAD-2022-12376126
Organisme : Italy Ministry of Health | Agenzia Italiana del Farmaco, Ministero della Salute (AIFA)
ID : GR-2021-12373337
Organisme : Ministero dell''''Istruzione, dell''''Università e della Ricerca (MIUR)
ID : 2022YMJXYT
Organisme : Ministero dell''''Istruzione, dell''''Università e della Ricerca (MIUR)
ID : P2022CMK43
Organisme : Ministero dell''''Istruzione, dell''''Università e della Ricerca (MIUR)
ID : 20225KH7BZ

Informations de copyright

Copyright © 2024 by The American Association of Immunologists, Inc.

Auteurs

Fortunata Carbone (F)

Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore," Consiglio Nazionale delle Ricerche, Napoli, Italy.
Unità di Neuroimmunologia, IRCCS-Fondazione Santa Lucia, Roma, Italy.

Alessandra Colamatteo (A)

Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II," Napoli, Italy.
ORCID: 0000-0002-9693-3985

Claudia La Rocca (C)

Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore," Consiglio Nazionale delle Ricerche, Napoli, Italy.

Maria Teresa Lepore (MT)

Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore," Consiglio Nazionale delle Ricerche, Napoli, Italy.
ORCID: 0000-0002-4701-6902

Claudia Russo (C)

D.A.I. Medicina di Laboratorio e Trasfusionale, Azienda Ospedaliera Universitaria "Federico II," Napoli, Italy.
ORCID: 0000-0001-5869-4445

Giusy De Rosa (G)

Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II," Napoli, Italy.

Alessandro Matarese (A)

Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli "Federico II," Napoli, Italy.
ORCID: 0009-0008-7325-1691

Claudio Procaccini (C)

Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore," Consiglio Nazionale delle Ricerche, Napoli, Italy.
Unità di Neuroimmunologia, IRCCS-Fondazione Santa Lucia, Roma, Italy.

Giuseppe Matarese (G)

Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore," Consiglio Nazionale delle Ricerche, Napoli, Italy.
Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II," Napoli, Italy.
ORCID: 0000-0001-9429-0616

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Eucaryotes › Animaux › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Metabolic Plasticity of Regulatory T Cells in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Plasticité cellulaire › Metabolic Plasticity of Regulatory T Cells in...