Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression.
Mast Cells
/ metabolism
Animals
Mice
Humans
Cytokines
/ metabolism
Cell Survival
/ genetics
Ribonuclease, Pancreatic
/ metabolism
Ribonucleases
/ metabolism
Gene Expression Regulation
RNA-Binding Proteins
/ metabolism
Mice, Inbred C57BL
Cell Proliferation
Inflammation
/ metabolism
Transcription Factors
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
22
04
2024
revised:
17
05
2024
accepted:
22
05
2024
medline:
4
6
2024
pubmed:
4
6
2024
entrez:
3
6
2024
Statut:
epublish
Résumé
Post-transcriptional regulation of immune-related transcripts by RNA-binding proteins (RBPs) impacts immune cell responses, including mast cell functionality. Despite their importance in immune regulation, the functional role of most RBPs remains to be understood. By manipulating the expression of specific RBPs in murine mast cells, coupled with mass spectrometry and transcriptomic analyses, we found that the Regnase family of proteins acts as a potent regulator of mast cell physiology. Specifically, Regnase-1 is required to maintain basic cell proliferation and survival, whereas both Regnase-1 and -3 cooperatively regulate the expression of inflammatory transcripts upon activation, with
Identifiants
pubmed: 38830770
pii: 7/8/e202402784
doi: 10.26508/lsa.202402784
pii:
doi:
Substances chimiques
Cytokines
0
Ribonuclease, Pancreatic
EC 3.1.27.5
regnase-1, mouse
EC 3.1.-
Zc3h12a protein, mouse
EC 3.1.-
Ribonucleases
EC 3.1.-
RNA-Binding Proteins
0
ZC3H12A protein, human
EC 3.1.-
Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 Bataclan et al.