Hand Rejuvenation with Customizable Hybrid Fillers: Premixed Calcium Hydroxyapatite and Hyaluronic Acid.
CaHA
Filler
Hand rejuvenation
Hybrid
Journal
Aesthetic plastic surgery
ISSN: 1432-5241
Titre abrégé: Aesthetic Plast Surg
Pays: United States
ID NLM: 7701756
Informations de publication
Date de publication:
03 Jun 2024
03 Jun 2024
Historique:
received:
07
04
2024
accepted:
13
05
2024
medline:
4
6
2024
pubmed:
4
6
2024
entrez:
3
6
2024
Statut:
aheadofprint
Résumé
Hand aging is a prevalent concern characterized by the atrophy of local soft tissues and increased visibility of vessels and tendons. Hyaluronic acid (HA) and calcium hydroxyapatite (CaHA) are well-established treatments for addressing this issue. While hybrid filler containing HA and CaHA has been proposed for facial rejuvenation, studies investigating its efficacy for hand rejuvenation are lacking. This study aims to assess the safety and efficacy of a premixed hybrid filler containing calcium hydroxyapatite (CaHA) and hyaluronic acid (HA) for hand rejuvenation. A prospective, double-blind, controlled trial was conducted. The control arm (CA) received conventional subdermal treatment with CaHA at a 1:1 dilution. The intervention arm (IA) underwent hybrid treatment, consisting of CaHA at a 1:1 dilution combined with 1 ml of low-density HA. Evaluation was performed subjectively using the Global Aesthetic Improvement Scale (GAIS) and the Manchester Hand Grading System (MHGS), and objectively using cutometry, corneometry, and ultrasound. Both the CA and the IA exhibited high rates of patient satisfaction and satisfaction as assessed by blinded evaluators. Although numerical superiority was observed in the IA, no statistical difference was found between the two groups. Significant improvements in hydration, elasticity, and skin thickness were observed in both arms, with no discernible difference between them. Greater ultrasound echogenicity was noted in the IA, which, as indicated by existing literature, may suggest enhanced biostimulation. No adverse effects were reported in either arm. Premixed filler containing HA and CaHA for hand rejuvenation appears to be a safe and effective approach. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Identifiants
pubmed: 38831064
doi: 10.1007/s00266-024-04145-4
pii: 10.1007/s00266-024-04145-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.
Références
Shamban AT (2009) Combination hand rejuvenation procedures. Aesthet Surg J 29(5):409–413. https://doi.org/10.1016/j.asj.2009.08.003
doi: 10.1016/j.asj.2009.08.003
pubmed: 19825471
Zhou J, Xie Y, Wang WJ, Herrler T, Hang RL, Zhao PJ, Zhou SZ, Li QF (2017) Hand rejuvenation by targeted volume restoration of the dorsal fat compartments. Aesthet Surg J 38(1):92–100. https://doi.org/10.1093/asj/sjx091
doi: 10.1093/asj/sjx091
pubmed: 29117295
Jakubietz RG, Jakubietz MG, Kloss D, Gruenert JG (2005) Defining the basic aesthetics of the hand. Aesthet Plast Surg 29(6):546–551. https://doi.org/10.1007/s00266-005-0100-6
doi: 10.1007/s00266-005-0100-6
Fabi SG, Goldman MP (2012) Hand rejuvenation: a review and our experience. Dermatol Surg 38(7 Pt 2):1112–1127. https://doi.org/10.1111/j.1524-4725.2011.02291.x
doi: 10.1111/j.1524-4725.2011.02291.x
pubmed: 22268976
Butterwick K, Sadick N (2016) Hand rejuvenation using a combination approach. Dermatol Surg 42(Suppl 2):S108–S118. https://doi.org/10.1097/DSS.0000000000000687
doi: 10.1097/DSS.0000000000000687
pubmed: 27128236
Goldman MP, Moradi A, Gold MH, Friedmann DP, Alizadeh K, Adelglass JM, Katz BE (2018) Calcium hydroxylapatite dermal filler for treatment of dorsal hand volume loss: results from a 12 Month, multicenter, randomized blinded trial. Dermatol Surg 44(1):75–83. https://doi.org/10.1097/DSS.0000000000001203
doi: 10.1097/DSS.0000000000001203
pubmed: 28562435
Busso M, Applebaum D (2007) Hand augmentation with radiesse (calcium hydroxylapatite). Dermatol Ther 20(6):385–387. https://doi.org/10.1111/j.1529-8019.2007.00153.x
doi: 10.1111/j.1529-8019.2007.00153.x
pubmed: 18093011
Figueredo VO, Miot HA, Soares Dias J, Nunes GJB, Barros de Souza M, Bagatin E (2020) Efficacy and safety of 2 injection techniques for hand biostimulatory treatment with diluted calcium hydroxylapatite. Dermatol Surg 46(Suppl 1):S54–S61. https://doi.org/10.1097/DSS.0000000000002334
doi: 10.1097/DSS.0000000000002334
pubmed: 32976172
González N, Goldberg DJ (2019) Evaluating the effects of injected calcium hydroxylapatite on changes in human skin elastin and proteoglycan formation. Dermatol Surg 45(4):547–551. https://doi.org/10.1097/DSS.0000000000001809
doi: 10.1097/DSS.0000000000001809
pubmed: 30893178
Williams S, Tamburic S, Stensvik H, Weber M (2009) Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands. J Cosmet Dermatol 8(3):216–225. https://doi.org/10.1111/j.1473-2165.2009.00447.x
doi: 10.1111/j.1473-2165.2009.00447.x
pubmed: 19735521
Streker M, Reuther T, Krueger N, Kerscher M (2013) Stabilized hyaluronic acid-based gel of non-animal origin for skin rejuvenation: face, hand, and décolletage. J Drugs Dermatol 12(9):990–994
pubmed: 24002145
Brandt FS, Cazzaniga A, Strangman N, Coleman J, Axford-Gatley R (2012) Long-term effectiveness and safety of small gel particle hyaluronic acid for hand rejuvenation. Dermatol Surg 38(7 Pt 2):1128–1135. https://doi.org/10.1111/j.1524-4725.2011.02282.x
doi: 10.1111/j.1524-4725.2011.02282.x
pubmed: 22243484
Chang JW, Koo WY, Kim EK, Lee SW, Lee JH (2020) Facial rejuvenation using a mixture of calcium hydroxylapatite filler and hyaluronic acid filler. J Craniofac Surg 31(1):e18–e21. https://doi.org/10.1097/SCS.0000000000005809
doi: 10.1097/SCS.0000000000005809
pubmed: 31403504
Fakih-Gomez N, Kadouch J (2022) Combining calcium hydroxylapatite and hyaluronic acid fillers for aesthetic indications: efficacy of an innovative hybrid filler. Aesthet Plast Surg 46(1):373–381. https://doi.org/10.1007/s00266-021-02479-x
doi: 10.1007/s00266-021-02479-x
Kadouch J, Fakih-Gomez N (2022) A hybrid filler: combining calcium hydroxylapatite and hyaluronic acid fillers for aesthetic indications. Am J Cosmet Surg 39(3):182–189. https://doi.org/10.1177/07488068211016135
doi: 10.1177/07488068211016135
Yag-Howard C, DeNigris J (2021) Novel filler technique: hyaluronic acid and calcium hydroxylapetite mixture resulting in favorable esthetic and longevity outcomes. Int J Womens Dermatol 7(5 Pt B):817–819. https://doi.org/10.1016/j.ijwd.2021.09.008
doi: 10.1016/j.ijwd.2021.09.008
pubmed: 35028387
pmcid: 8714586
Fakih-Gomez N, Muñoz-Gonzalez C, Porcar Plana CA, Verano Garcia A, Kadouch J (2024) Standarized protocols for hybrid filler application in aesthetic medicine. Am J Cosmet Surg. https://doi.org/10.1177/07488068241227278
doi: 10.1177/07488068241227278
Qassem M, Kyriacou P (2019) Review of modern techniques for the assessment of skin hydration. Cosmetics 6(1):19. https://doi.org/10.3390/cosmetics6010019
doi: 10.3390/cosmetics6010019
Hua W, Fan LM, Dai R, Luan M, Xie H, Li AQ, Li L (2017) Comparison of two series of non-invasive instruments used for the skin physiological properties measurements: the DermaLab
doi: 10.1111/srt.12303
pubmed: 27637867
Frank K, Koban K, Targosinski S, Erlbacher K, Schenck TL, Casabona G, Braz AV, Pavicic T, Cotofana S (2018) The anatomy behind adverse events in hand volumizing procedures: retrospective evaluations of 11 years of experience. Plast Reconstr Surg 141(5):650e–662e. https://doi.org/10.1097/PRS.0000000000004211
doi: 10.1097/PRS.0000000000004211
pubmed: 29697606
Sattler G et al (2014) Efficacy of calcium hydroxylapatite filler versus hyaluronic acid filler in hand augmentation. Aktuelle Dermatol 40(11):445–451. https://doi.org/10.1055/s-0034-1378110
doi: 10.1055/s-0034-1378110
Lacarrubba F, Tedeschi A, Nardone B, Micali G (2008) Mesotherapy for skin rejuvenation: assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross-sectional B-mode scanning. Dermatol Ther 21(Suppl 3):S1-5. https://doi.org/10.1111/j.1529-8019.2008.00234.x
doi: 10.1111/j.1529-8019.2008.00234.x
pubmed: 19076625
Belda Junior W, Chiacchio ND, Criado PR (2014) Tratado de dermatologia. Tratado de Dermatol, pp xli–2746
McGuire C, Boudreau C, Tang D (2022) Hand rejuvenation: a systematic review of techniques, outcomes, and complications. Aesthetic Plast Surg 46(1):437–449. https://doi.org/10.1007/s00266-021-02519-6
doi: 10.1007/s00266-021-02519-6
pubmed: 34382097