Predictors of health-related quality of life in a large cohort of adult patients living with sickle cell disease in France: the DREPAtient study.
DREPAtient study
France
SF-36
health-related quality of life
sickle cell disease
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2024
2024
Historique:
received:
22
01
2024
accepted:
22
04
2024
medline:
4
6
2024
pubmed:
4
6
2024
entrez:
4
6
2024
Statut:
epublish
Résumé
Sickle cell disease (SCD) is an inherited autosomal recessive disorder exhibiting a range of symptoms and acute and/or chronic complications that affect the quality of life. This study aimed to assess health-related quality of life (HRQoL) and to identify the associated factors in adult patients with SCD in France. DREPAtient is a cross-sectional, multicenter study conducted from June 2020 to April 2021 in France and in certain French overseas territories where SCD is highly prevalent. Sociodemographic and clinical data were collected online. HRQoL was assessed by the French version of the 36-Item Short Form Survey (SF-36) questionnaire. HRQoL determinants were identified using multivariable linear regression analysis. In total, 570 participants were included, mostly women (68.9%), with a mean age of 33.3 (±10.7) years. The highest mean score HRQoL was found in the Physical functioning domain (67.5 ± 21.8) and the lowest mean score in the General Health perception domain (37.7 ± 20.3). The mean score of the physical composite (PCS) and mental composite (MCS) of SF-36 summary scores was 40.6 ± 8.9 and 45.3 ± 9.8, respectively. Participants receiving oxygen therapy ( Adults with major SCD reported poor physical and mental HRQoL scores. Hospitalization for VOC/ACS, chronic complications, use of painkillers, perceived financial situation, and support from relatives are important predictors of HRQoL in SCD patients. Interventions to improve HRQoL outcomes SCD should be considered.
Sections du résumé
Background
UNASSIGNED
Sickle cell disease (SCD) is an inherited autosomal recessive disorder exhibiting a range of symptoms and acute and/or chronic complications that affect the quality of life. This study aimed to assess health-related quality of life (HRQoL) and to identify the associated factors in adult patients with SCD in France.
Methods
UNASSIGNED
DREPAtient is a cross-sectional, multicenter study conducted from June 2020 to April 2021 in France and in certain French overseas territories where SCD is highly prevalent. Sociodemographic and clinical data were collected online. HRQoL was assessed by the French version of the 36-Item Short Form Survey (SF-36) questionnaire. HRQoL determinants were identified using multivariable linear regression analysis.
Results
UNASSIGNED
In total, 570 participants were included, mostly women (68.9%), with a mean age of 33.3 (±10.7) years. The highest mean score HRQoL was found in the Physical functioning domain (67.5 ± 21.8) and the lowest mean score in the General Health perception domain (37.7 ± 20.3). The mean score of the physical composite (PCS) and mental composite (MCS) of SF-36 summary scores was 40.6 ± 8.9 and 45.3 ± 9.8, respectively. Participants receiving oxygen therapy (
Conclusion
UNASSIGNED
Adults with major SCD reported poor physical and mental HRQoL scores. Hospitalization for VOC/ACS, chronic complications, use of painkillers, perceived financial situation, and support from relatives are important predictors of HRQoL in SCD patients. Interventions to improve HRQoL outcomes SCD should be considered.
Identifiants
pubmed: 38832226
doi: 10.3389/fpubh.2024.1374805
pmc: PMC11144927
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1374805Investigateurs
Marieke Podevin
(M)
Gaëlle Thomas
(G)
Olivier Chassany
(O)
Issifou Yaya
(I)
Lisa Yombo-Kokule
(L)
Frédéric Galactéros
(F)
Damien Oudin Doglioni
(DO)
Odièvre-Montanié Marie-Hélène
(OM)
Benjamin Derbez
(B)
Christian Godart
(C)
Maryannick Lepetit
(M)
Tania Cassubie-Mercier
(T)
Tania Cassubie-Mercier
(T)
Sonia Pavan
(S)
Patricia Aguilar-Martinez
(P)
Jean-Benoït Arlet
(JB)
Giovanna Cannas
(G)
Abdourahim Chamouine
(A)
Maryse Etienne-Julan
(M)
Corinne Guitton
(C)
Sylvain Le Jeune
(S)
Gylna Loko
(G)
Corinne Pondarre
(C)
Informations de copyright
Copyright © 2024 Yaya, Pourageaud, Derbez, Odièvre, Oudin Doglioni, Podevin, Thomas, Yombo-Kokule, Godart, Lepetit, Cassubie-Mercier, Galacteros, Chassany and DREPAtient study group.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.