Does botulinum toxin affect psycho-social aspects in dystonia?
Body image
Botulinum toxin
Depression
Focal dystonia
Psycho-social correlates
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
04 Jun 2024
04 Jun 2024
Historique:
received:
19
03
2024
accepted:
06
05
2024
medline:
4
6
2024
pubmed:
4
6
2024
entrez:
4
6
2024
Statut:
aheadofprint
Résumé
Dystonia is a movement disorder in which sustained muscle contractions give rise to abnormal postures or involuntary movements. It is a disabling and disfiguring disorder that affects activities of daily living and gives people a bizarre appearance often associated with psychological morbidity, embarrassment and social avoidance. Intramuscular injection of botulinum toxin (BoNT) is the most effective treatment for motor symptoms in focal dystonia, but little is known about its impact on the psycho-social dimension. The main aim of this study was to evaluate psycho-social changes in patients with focal dystonia after starting BoNT treatment using self-reported scales. The Beck Depression Inventory (BDI-II), the 36-Item Short Form Health Survey (SF-36), the Body Uneasiness Test (BUT), the State-Trait Anxiety Inventory (STAI) and the Visual Analogue Scale (VAS) assessing body self-image, satisfaction with physical aspects, social avoidance, self-reported depression, and self-distress were completed by 11 patients with dystonia and 9 patients with hyperhidrosis as a control group before BoNT (T0). VAS was then performed after four weeks (T1) to assess whether BoNT induced changes in the psychosocial dimension. Our results showed that only depressive symptoms and rumination about body defects improved in patients with dystonia after BoNT treatment, while improvement in self-distress and satisfaction with physical aspects was also found in hyperhidrosis. Individuals with hyperhidrosis experience poorer psychological well-being and suffer from higher levels of distress compared to dystonic patients. This suggests that individuals with this disabling condition are more vulnerable to social impact than dystonic patients.
Identifiants
pubmed: 38832965
doi: 10.1007/s00702-024-02785-z
pii: 10.1007/s00702-024-02785-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Almohideb M, Aljihani M, Bukhari M, Algethami B, Asiri O, Alnamlah A (2021) The impact of hyperhidrosis on patients’ quality of life and daily activities. Int J Pharm Res 10(2–2021):77–83. https://doi.org/10.51847/zCOO8iVetA
doi: 10.51847/zCOO8iVetA
Beck AT, Steer RA, Brown G (1996) Beck depression inventory–II. Psychological assessment. https://doi.org/10.1037/t00742-000
Bergeron DP (2007) The relationship between body image dissatisfaction and psychological health: An exploration of body image in young adult men (Doctoral dissertation, The Ohio State University)
Bledsoe IO, Comella CL (2016) Botulinum toxin treatment of cervical dystonia. Sem. Neur. Vol. 36, No. 01, pp. 047–053. Thieme Medical Publishers. https://doi.org/10.1055/s-0035-1571210
Brazier JE, Harper R, Jones NM, O’cathain A, Thomas KJ, Usherwood T, Westlake L (1992) Validating the SF-36 health survey questionnaire: new outcome measure for primary care. Br Med J 305(6846):160–164. https://doi.org/10.1136/bmj.305.6846.160
doi: 10.1136/bmj.305.6846.160
Camargo CHF, Cattai L, Teive HAG (2015) Pain relief in cervical dystonia with botulinum toxin treatment. Toxins 7(6):2321–2335. https://doi.org/10.3390/toxins7062321
doi: 10.3390/toxins7062321
pubmed: 26110508
pmcid: 4488705
Carvalho GXD, Nunes APN, Moraes CL, Veiga GVD (2020) Body image dissatisfaction and associated factors in adolescents. Cien Saude Cole 25:2769–2782. https://doi.org/10.1590/1413-81232020257.27452018
doi: 10.1590/1413-81232020257.27452018
Cole R, Hallett M, Cohen LG (1995) Double-blind trial of botulinum toxin for treatment of focal hand dystonia. Mov Disord 10(4):466–471. https://doi.org/10.1002/mds.870100411
doi: 10.1002/mds.870100411
pubmed: 7565828
Colosimo C, Tiple D, Berardelli A (2012) Efficacy and safety of long-term botulinum toxin treatment in craniocervical dystonia: a systematic review. Neurotox Res 22:265–273. https://doi.org/10.1007/s12640-012-9314-y
doi: 10.1007/s12640-012-9314-y
pubmed: 22359151
Costanzo M, Belvisi D, Berardelli I, Maraone A, Baione V, Ferrazzano G, Cutrona C, Leodori G, Pasquini M, Conte A, Fabbrini G, Defazio G, Berardelli A (2021) Effect of Botulinum Toxin on Non-motor symptoms in cervical dystonia. Toxins 13(9):647. https://doi.org/10.3390/toxins13090647
doi: 10.3390/toxins13090647
pubmed: 34564651
pmcid: 8472845
Cuzzolaro M, Vetrone G, Marano G, Garfinkel PE (2006) The body uneasiness test (BUT): development and validation of a new body image assessment scale. Eat Weight Disord 11(1):1–13. https://doi.org/10.1007/bf03327738
doi: 10.1007/bf03327738
pubmed: 16801740
Davidescu EI, Odajiu I, Tulbă D, Mitrea I, Cucu C, Popescu BO (2021) Psychological traits and behavioural influences in patients with Dystonia-An Observational Cohort Study in a Romanian Neurology Department. Life 24(7):612. https://doi.org/10.3390/life11070612
doi: 10.3390/life11070612
Degirmenci Y, Oyekcin DG, Bakar C, Kurklu N (2013) Anxiety and depression in primary and secondary dystonia: a burden on health related quality of life. Neurol Psychiatry Brain Res 19(2):80–85. https://doi.org/10.1016/j.npbr.2013.01.002
doi: 10.1016/j.npbr.2013.01.002
Dong H, Fan S, Luo Y, Peng B (2018) Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm. Neuropsychiatr Dis Treat 33–36. https://doi.org/10.2147/ndt.s181820
Dressler D, Adib Saberi F, Rosales RL (2021) Botulinum toxin therapy of dystonia. J Neural Transm 128(4):531–537. https://doi.org/10.1007/s00702-020-02266-z
doi: 10.1007/s00702-020-02266-z
pubmed: 33125571
Green JA (2021) Too many zeros and/or highly skewed? A tutorial on modelling health behaviour as count data with Poisson and negative binomial regression. Health Psychol Behav Med 6(91):436–455. https://doi.org/10.1080/21642850.2021.1920416
doi: 10.1080/21642850.2021.1920416
Grütz K, Klein C (2021) Dystonia updates: definition, nomenclature, clinical classification, and etiology. J Neural Transm 128:395–404. https://doi.org/10.1007/s00702-021-02314-2
doi: 10.1007/s00702-021-02314-2
pubmed: 33604773
Henning MAS, Barati F, Jemec GBE (2023) Quality of life in individuals with primary hyperhidrosis: a systematic review and meta-analysis. Clin Auton Res 33(4):519–528. https://doi.org/10.1007/s10286-023-00954-w
doi: 10.1007/s10286-023-00954-w
pubmed: 37507605
Huang W, Foster JA, Rogachefsky AS (2000). Pharmacology of botulinum toxin. J Am Acad Dermatol. 43(2 Pt 1):249-59. https://doi.org/10.1067/mjd.2000.105567 .
Kaji R, Bhatia K, Graybiel AM (2018) Pathogenesis of dystonia: is it of cerebellar or basal ganglia origin? J Neurol Neurosurg Psychiatry 89(5):488–492. https://doi.org/10.1136/jnnp-2017-316250
doi: 10.1136/jnnp-2017-316250
pubmed: 29089396
Kim HY (2013) Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. Restor Dent Endod 38(1):52–54. https://doi.org/10.5395/rde.2013.38.1.52
doi: 10.5395/rde.2013.38.1.52
pubmed: 23495371
pmcid: 3591587
Müller J, Kemmler G, Wissel J, Schneider A, Voller B, Grossmann J, Diez J, Homann N, Wenning GK, Schnider P, Poewe W; Austrian Botulinum Toxin and Dystonia Study Group (2002). The impact of blepharospasm and cervical dystonia on health-related quality of life and depression. J Neurol 249(7):842-6. https://doi.org/10.1007/s00415-002-0733-1
doi: 10.1007/s00415-002-0733-1
pubmed: 12140667
Ochudlo S, Bryniarski P, Opala G (2007) Botulinum toxin improves the quality of life and reduces the intensification of depressive symptoms in patients with blepharospasm. Parkinsonism Relat Disord 13(8):505–508. https://doi.org/10.1016/j.parkreldis.2007.03.006
doi: 10.1016/j.parkreldis.2007.03.006
pubmed: 17543569
Parashar K, Adlam T, Potts G (2023) The impact of hyperhidrosis on quality of life: a review of the literature. Am J Clin Dermatol 24(2):187–198. https://doi.org/10.1007/s40257-022-00743-7
doi: 10.1007/s40257-022-00743-7
pubmed: 36622502
pmcid: 9838291
Parsaik AK, Mascarenhas SS, Hashmi A, Prokop LJ, John V, Okusaga O, Singh B (2016) Role of Botulinum Toxin in Depression. J Psychiatr Pract 22(2):99–110. https://doi.org/10.1097/PRA.0000000000000136
doi: 10.1097/PRA.0000000000000136
pubmed: 27138078
Pekmezovic T, Svetel M, Ivanovic N, Dragasevic N, Petrovic I, Tepavcevic DK, Kostic VS (2009) Quality of life in patients with focal dystonia. Clin Neurol Neurosurg 111(2):161–164. https://doi.org/10.1016/j.clineuro.2008.09.023
doi: 10.1016/j.clineuro.2008.09.023
pubmed: 18995953
Sharma N (2019) Neuropathology of dystonia. Tremor other hyperkinet. Mov 9. https://doi.org/10.7916/d8-j6sx-b156
doi: 10.7916/d8-j6sx-b156
Smith AR, Li N, Joiner TE (2011) The pursuit of success: can status aspirations negatively affect body satisfaction? J Soc Clin Psychol 30(5):531–547. https://doi.org/10.1521/jscp.2011.30.5.531
doi: 10.1521/jscp.2011.30.5.531
Spielberger CD (1970) Manual for the State-Trait Anxiety Inventory (self-evaluation questionnaire)
Steeves TD, Day L, Dykeman J, Jette N, Pringsheim T (2012) The prevalence of primary dystonia: a systematic review and meta-analysis. Mov Disord 27(14):1789–1796. https://doi.org/10.1002/mds.25244
doi: 10.1002/mds.25244
pubmed: 23114997