The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study.


Journal

ASAIO journal (American Society for Artificial Internal Organs : 1992)
ISSN: 1538-943X
Titre abrégé: ASAIO J
Pays: United States
ID NLM: 9204109

Informations de publication

Date de publication:
05 Jun 2024
Historique:
medline: 4 6 2024
pubmed: 4 6 2024
entrez: 4 6 2024
Statut: aheadofprint

Résumé

Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective observational study was to determine whether acute exercise modulates two-hit hypothesis mediators associated with GI bleeding in patients with a CF-LVAD. Twenty-two patients with CF-LVADs performed acute exercise either on a cycle ergometer for approximately 10 minutes or on a treadmill for 30 minutes. Blood samples were taken pre- and post-exercise to analyze hemostatic and angiogenic biomarkers. Acute exercise resulted in an increased platelet count (p < 0.00001) and platelet function (induced by adenosine diphosphate, p = 0.0087; TRAP-6, p = 0.0005; ristocetin, p = 0.0009). Additionally, high-molecular-weight vWF multimers (p < 0.00001), vWF collagen-binding activity (p = 0.0012), factor VIII (p = 0.034), angiopoietin-1 (p = 0.0026), and vascular endothelial growth factor (p = 0.0041) all increased after acute exercise. This pilot work demonstrates that acute exercise modulated two-hit hypothesis mediators associated with GI bleeding in patients with CF-LVADs.

Identifiants

pubmed: 38833540
doi: 10.1097/MAT.0000000000002246
pii: 00002480-990000000-00501
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Belgian Fonds voor Hartchirurgie
ID : N. 489618
Organisme : the National Health and Medical Research Council Centre
ID : APP1079421

Informations de copyright

Copyright © ASAIO 2024.

Déclaration de conflit d'intérêts

Disclosure: The authors have no conflicts of interest to report.

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Auteurs

Chris H H Chan (CHH)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
School of Engineering and Built Environment, Griffith University, Gold Coast, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.
Innovative Device & Engineering Applications Laboratory, Texas Heart Institute, Houston, Texas.

Margaret R Passmore (MR)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.

Oystein Tronstad (O)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Physiotherapy Department, The Prince Charles Hospital, Brisbane, Australia.

Helen Seale (H)

Physiotherapy Department, The Prince Charles Hospital, Brisbane, Australia.

Mahe Bouquet (M)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.

Nicole White (N)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.

Jun Teruya (J)

Departments of Pathology & Immunology, Pediatrics, and Medicine, Baylor College of Medicine, Houston, Texas.

Airlie Hogan (A)

Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia.

David Platts (D)

Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia.

Wandy Chan (W)

Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia.
Cardio-Vascular Molecular and Therapeutics Translational Research Group, University of Queensland, Brisbane, Australia.

Alexander M Dashwood (AM)

Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia.
Cardio-Vascular Molecular and Therapeutics Translational Research Group, University of Queensland, Brisbane, Australia.

David C McGiffin (DC)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Department of Cardiothoracic Surgery and Transplantation, The Alfred Hospital, Melbourne, Australia.
Department of Cardiothoracic Surgery, Monash University, Melbourne, Australia.

Andrew J Maiorana (AJ)

Allied Health Department, Fiona Stanley Hospital, Perth, Australia.
Curtin School of Allied Health, Curtin University, Perth, Australia.

Christopher S Hayward (CS)

Heart Failure and Transplant Unit, St. Vincent's Hospital, Sydney, Australia.
Victor Chang Cardiac Research Institute, Sydney, Australia.

Michael J Simmonds (MJ)

Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.

Geoff D Tansley (GD)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
School of Engineering and Built Environment, Griffith University, Gold Coast, Australia.

Jacky Y Suen (JY)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.

John F Fraser (JF)

From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.

Bart Meyns (B)

Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium; and.

Libera Fresiello (L)

Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium; and.
Group of Cardiovascular and Respiratory Physiology, University of Twente, Enschede, The Netherlands.

Steven Jacobs (S)

Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium; and.

Classifications MeSH