An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 Jun 2024
04 Jun 2024
Historique:
received:
27
09
2023
accepted:
13
05
2024
medline:
5
6
2024
pubmed:
5
6
2024
entrez:
4
6
2024
Statut:
epublish
Résumé
Precise neurostimulation can revolutionize therapies for neurological disorders. Electrode-based stimulation devices face challenges in achieving precise and consistent targeting due to the immune response and the limited penetration of electrical fields. Ultrasound can aid in energy propagation, but transcranial ultrasound stimulation in the deep brain has limited spatial resolution caused by bone and tissue scattering. Here, we report an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal pressure of 100 kPa to modulate the activity of neurons. ImPULS is a fully-encapsulated, flexible piezoelectric micromachined ultrasound transducer that incorporates a biocompatible piezoceramic, potassium sodium niobate [(K,Na)NbO
Identifiants
pubmed: 38834558
doi: 10.1038/s41467-024-48748-6
pii: 10.1038/s41467-024-48748-6
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Proto-Oncogene Proteins c-fos
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4601Informations de copyright
© 2024. The Author(s).
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