Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes.

Journal

Nature immunology

ISSN: 1529-2916

Titre abrégé: Nat Immunol

Pays: United States

ID NLM: 100941354

Informations de publication

Date de publication:
04 Jun 2024

Historique:

received: 13 03 2023

accepted: 25 04 2024

medline: 5 6 2024

pubmed: 5 6 2024

entrez: 4 6 2024

Statut: aheadofprint

Résumé

Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events using dedicated shape-sensing pathways. However, how shape sensing affects immune cell function is mostly unknown. Here, we identify a shape-sensing mechanism that increases the expression of the chemokine receptor CCR7 and guides dendritic cell migration from peripheral tissues to lymph nodes at steady state. This mechanism relies on the lipid metabolism enzyme cPLA

Identifiants

DOI: 10.1038/s41590-024-01856-3 PMID: 38834865

pubmed: 38834865

doi: 10.1038/s41590-024-01856-3

pii: 10.1038/s41590-024-01856-3

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : Fondation pour la Recherche Médicale (Foundation for Medical Research in France)

ID : SMC202006012351

Organisme : Human Frontier Science Program (HFSP)

ID : RGP0032-2022

Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)

ID : 666003

Organisme : Agence Nationale de la Recherche (French National Research Agency)

ID : ANR-20-CE15-0023 (InfEx).

Organisme : Agence Nationale de la Recherche (French National Research Agency)

ID : ANR-10-IDEX-0001-02

Informations de copyright

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