Identification of a longevity gene through evolutionary rate covariation of insect mito-nuclear genomes.
Journal
Nature aging
ISSN: 2662-8465
Titre abrégé: Nat Aging
Pays: United States
ID NLM: 101773306
Informations de publication
Date de publication:
04 Jun 2024
04 Jun 2024
Historique:
received:
03
07
2023
accepted:
02
05
2024
medline:
5
6
2024
pubmed:
5
6
2024
entrez:
4
6
2024
Statut:
aheadofprint
Résumé
Oxidative phosphorylation, essential for energy metabolism and linked to the regulation of longevity, involves mitochondrial and nuclear genes. The functions of these genes and their evolutionary rate covariation (ERC) have been extensively studied, but little is known about whether other nuclear genes not targeted to mitochondria evolutionarily and functionally interact with mitochondrial genes. Here we systematically examined the ERC of mitochondrial and nuclear benchmarking universal single-copy ortholog (BUSCO) genes from 472 insects, identifying 75 non-mitochondria-targeted nuclear genes. We found that the uncharacterized gene CG11837-a putative ortholog of human DIMT1-regulates insect lifespan, as its knockdown reduces median lifespan in five diverse insect species and Caenorhabditis elegans, whereas its overexpression extends median lifespans in fruit flies and C. elegans and enhances oxidative phosphorylation gene activity. Additionally, DIMT1 overexpression protects human cells from cellular senescence. Together, these data provide insights into the ERC of mito-nuclear genes and suggest that CG11837 may regulate longevity across animals.
Identifiants
pubmed: 38834883
doi: 10.1038/s43587-024-00641-z
pii: 10.1038/s43587-024-00641-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32071665
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32230015
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32325044
Organisme : National Science Foundation (NSF)
ID : DEB-2110404
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
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