Effects of temporal IFNγ exposure on macrophage phenotype and secretory profile: exploring GMP-Compliant production of a novel subtype of regulatory macrophages (Mreg
Cell therapy
M1/M2 macrophages
Macrophages
Monocytes
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
04 Jun 2024
04 Jun 2024
Historique:
received:
17
04
2024
accepted:
18
05
2024
medline:
5
6
2024
pubmed:
5
6
2024
entrez:
4
6
2024
Statut:
epublish
Résumé
Macrophages are involved in tissue homeostasis, angiogenesis and immunomodulation. Proangiogenic and anti-inflammatory macrophages (regulatory macrophages, Mreg) can be differentiated in-vitro from CD14 To scrutinize the potential impact of temporal IFNγ exposure on macrophage differentiation as such exposure may lead to the emergence of a distinct and novel macrophage subtype. Differentiation of human CD14 Mreg and Mreg Exposing CD14
Sections du résumé
BACKGROUND
BACKGROUND
Macrophages are involved in tissue homeostasis, angiogenesis and immunomodulation. Proangiogenic and anti-inflammatory macrophages (regulatory macrophages, Mreg) can be differentiated in-vitro from CD14
AIM OF THE STUDY
OBJECTIVE
To scrutinize the potential impact of temporal IFNγ exposure on macrophage differentiation as such exposure may lead to the emergence of a distinct and novel macrophage subtype.
METHODS
METHODS
Differentiation of human CD14
RESULTS
RESULTS
Mreg and Mreg
CONCLUSION
CONCLUSIONS
Exposing CD14
Identifiants
pubmed: 38835045
doi: 10.1186/s12967-024-05336-y
pii: 10.1186/s12967-024-05336-y
doi:
Substances chimiques
Interferon-gamma
82115-62-6
Lipopolysaccharide Receptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
534Subventions
Organisme : Ferring Ventures GmbH
ID : Research Grant
Informations de copyright
© 2024. The Author(s).
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