The changing epidemiology of

To describe the epidemiology of healthcare-associated Time-series analysis. Two Canadian tertiary care hospitals based in Montréal, Québec. Patients with a positive assay for toxigenic The incidence of HA-CDI and antibiotic utilization from 2003 to 2020 were analyzed with available The incidence of HA-CDI decreased between 2003 and 2020 at both hospitals from 26.5 cases per 10,000 patient-days in 2003 to 4.9 cases per 10,000 patient-days in 2020 respectively. Over the study period, there were an increase in the utilization of third-generation cephalosporins and a decrease in usage of fluoroquinolones and clindamycin. A decrease in fluoroquinolone utilization was associated with a significant decrease in HA-CDI incidence as well as decrease in the NAP1/027 strain by approximately 80% in both hospitals. Decreased utilization of fluoroquinolones in two Québec hospitals was associated with a decrease in the incidence of HA-CDI and a genotype shift from NAP1/027 to non-NAP1/027 strains.

Informations de copyright

© The Author(s) 2024.

Déclaration de conflit d'intérêts

YL received salary support from the Fonds de Recherche du Québec outside of this work. VGL received consulting fees from Ferring Inc., Merck Inc., and Xediton Pharmaceuticals Inc. outside of this work. All other authors report no competing interests.