Optimisation of vitamin D status in global populations.
Cholecalciferol
Deficiency
Ergocalciferol
Population
Supplementation
Vitamin D
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105
Informations de publication
Date de publication:
05 Jun 2024
05 Jun 2024
Historique:
received:
23
03
2024
accepted:
10
05
2024
medline:
5
6
2024
pubmed:
5
6
2024
entrez:
5
6
2024
Statut:
aheadofprint
Résumé
Vitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary markedly around the world and are influenced by many factors including sun exposure, skin pigmentation, covering, season and supplement use. Whilst overt vitamin D deficiency with biochemical consequences presents an increased risk of severe sequelae such as rickets, osteomalacia or cardiomyopathy and usually warrants prompt replacement treatment, the role of vitamin D supplementation in the population presents a different set of considerations. Here the issue is to keep, on average, the population at a level whereby the risk of adverse health outcomes in the population is minimised. This position paper, which complements recently published work from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, addresses key considerations regarding vitamin D assessment and intervention from the population perspective. This position paper, on behalf of the International Osteoporosis Foundation Vitamin D Working Group, summarises the burden and possible amelioration of vitamin D deficiency in global populations. It addresses key issues including screening, supplementation and food fortification.
Identifiants
pubmed: 38836946
doi: 10.1007/s00198-024-07127-z
pii: 10.1007/s00198-024-07127-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.
Références
Chevalley T, Brandi ML, Cashman KD et al (2022) Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group. Aging Clin Exp Res 34:2603–2623
pubmed: 36287325
pmcid: 9607746
doi: 10.1007/s40520-022-02279-6
Wahl DA, Cooper C, Ebeling PR et al (2012) A global representation of vitamin D status in healthy populations. Arch Osteoporos 7:155–172
pubmed: 23225293
doi: 10.1007/s11657-012-0093-0
Cashman KD (2022) Global differences in vitamin D status and dietary intake: a review of the data. Endocr Connect 11;11(1):e210282
Holick MF, Garabedian M (2006) Vitamin D: photobiology, metabolism, mechanisms of action, and clinical applications. In: Favus MJ (ed) Primer on the metabolic bone diseases and mineral metabolism. ASBMR, Chicago, pp 106–114
Uday S, Hogler W (2019) Spot the silent sufferers: a call for clinical diagnostic criteria for solar and nutritional osteomalacia. J Steroid Biochem Mol Biol 188:141–146
pubmed: 30654108
doi: 10.1016/j.jsbmb.2019.01.004
Sempos CT, Durazo-Arvizu RA, Fischer PR, Munns CF, Pettifor JM, Thacher TD (2021) Serum 25-hydroxyvitamin D requirements to prevent nutritional rickets in Nigerian children on a low-calcium diet-a multivariable reanalysis. Am J Clin Nutr 114:231–237
pubmed: 33742199
doi: 10.1093/ajcn/nqab048
Folino D, Durieux-Paillard S, Biver E, Ferrari S, Richtering SS (2023) New reimbursement criteria for vitamin D measurements: what about our migrant patients? Rev Med Suisse 19:761–764
pubmed: 37133957
Scientific Advisory Committee on Nutrition (2016) Vitamin D and Health Report. Public Health England, London
Institute of Medicine (2010) In: Ross T, Yaktine, Valle D (eds) DRI's for calcium and vitamin D. Institute of Medicine, Washington D.C
EFSA Panel on Dietetic Products N, Allergies (2016) Dietary reference values for vitamin D. EFSA J 14:e04547
doi: 10.2903/j.efsa.2016.4547
Sempos CT, Binkley N (2020) 25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis. Public Health Nutr 23:1153–1164
pubmed: 32301688
pmcid: 7167380
doi: 10.1017/S1368980019005251
Cashman KD, Sheehy T, O’Neill CM (2019) Is vitamin D deficiency a public health concern for low middle income countries? A systematic literature review. Eur J Nutr 58:433–453
pubmed: 29344677
doi: 10.1007/s00394-018-1607-3
Cui A, Zhang T, Xiao P, Fan Z, Wang H, Zhuang Y (2023) Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: a pooled analysis of 7.9 million participants. Front Nutr 10:1070808
pubmed: 37006940
pmcid: 10064807
doi: 10.3389/fnut.2023.1070808
Sempos CT, Vesper HW, Phinney KW, Thienpont LM, Coates PM (2012) Vitamin D status as an international issue: national surveys and the problem of standardization. Scand J Clin Lab Invest 72:32–40
(2019) Comprehensive National Nutrition Survey (CNNS) National Report. Ministry of Health and Family Welfare (MoHFW), Government of India, UNICEF and Population Council, New Delhi, India
Mogire RM, Mutua A, Kimita W, Kamau A, Bejon P, Pettifor JM, Adeyemo A, Williams TN, Atkinson SH (2020) Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis. Lancet Glob Health 8:e134–e142
pubmed: 31786117
doi: 10.1016/S2214-109X(19)30457-7
Ross AC, Manson JE, Abrams SA et al (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58
pubmed: 21118827
doi: 10.1210/jc.2010-2704
Carter GD, Berry J, Durazo-Arvizu R et al (2018) Hydroxyvitamin D assays: an historical perspective from DEQAS. J Steroid Biochem Mol Biol 177:30–35
pubmed: 28734989
doi: 10.1016/j.jsbmb.2017.07.018
Sempos CT, Heijboer AC, Bikle DD et al (2018) Vitamin D assays and the definition of hypovitaminosis D: results from the first international conference on controversies in vitamin D. Br J Clin Pharmacol 84(10):2194–2207
Bouillon R (2017) Comparative analysis of nutritional guidelines for vitamin D. Nat Rev Endocrinol 13:466–479
pubmed: 28387318
doi: 10.1038/nrendo.2017.31
Dai Z, McKenzie JE, McDonald S, Baram L, Page MJ, Allman-Farinelli M, Raubenheimer D, Bero LA (2021) Assessment of the methods used to develop vitamin D and calcium recommendations-a systematic review of bone health guidelines. Nutrients 13(7):2423
Binkley N, Dawson-Hughes B, Durazo-Arvizu R, Thamm M, Tian L, Merkel JM, Jones JC, Carter GD, Sempos CT (2017) Vitamin D measurement standardization: the way out of the chaos. J Steroid Biochem Mol Biol 173:117–121
pubmed: 27979577
doi: 10.1016/j.jsbmb.2016.12.002
Sempos CT, Durazo-Arvizu RA, Binkley N, Jones J, Merkel JM, Carter GD (2016) Developing vitamin D dietary guidelines and the lack of 25-hydroxyvitamin D assay standardization: the ever-present past. J Steroid Biochem Mol Biol 164:115–119
pubmed: 26321386
doi: 10.1016/j.jsbmb.2015.08.027
Binkley N, Sempos CT (2014) Standardizing vitamin D assays: the way forward. J Bone Miner Res 29:1709–1714
pubmed: 24737265
doi: 10.1002/jbmr.2252
Rahme M, Al-Shaar L, Singh R et al (2018) Limitations of platform assays to measure serum 25OHD level impact on guidelines and practice decision making. Metab Clin Exp 89:1–7
pubmed: 30227144
doi: 10.1016/j.metabol.2018.09.003
Hodge AM (2020) The need for vitamin D assay standardisation in research. Public Health Nutr 23:3283
pubmed: 32981564
pmcid: 7737040
doi: 10.1017/S1368980020003328
Bouillon R, Verlinden L, Verstuyf A (2016) Is vitamin D2 really bioequivalent to vitamin D3? Endocrinology 157:3384–3387
pubmed: 27580803
doi: 10.1210/en.2016-1528
Tripkovic L, Lambert H, Hart K et al (2012) Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr 95:1357–1364
pubmed: 22552031
pmcid: 3349454
doi: 10.3945/ajcn.111.031070
Weaver CM, Dawson-Hughes B, Rizzoli R, Heaney RP (2018) Nutritional support of osteoporosis primer of metabolic bone diseases and disorders of metabolism. ASBMR
Quesada-Gomez JM, Bouillon R (2018) Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int 29:1697–1711
pubmed: 29713796
doi: 10.1007/s00198-018-4520-y
Mazess RB, Bischoff-Ferrari HA, Dawson-Hughes B (2021) Vitamin D: bolus is bogus-a narrative review. JBMR Plus 5:e10567
pubmed: 34950828
pmcid: 8674779
doi: 10.1002/jbm4.10567
Zittermann A, Berthold HK, Pilz S (2021) The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr 75:980–987
pubmed: 32855522
doi: 10.1038/s41430-020-00725-0
Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ (2010) Vitamin D: metabolism. Endocrinol Metab Clin N Am 39:243–253 table of contents
doi: 10.1016/j.ecl.2010.02.002
Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC (2010) Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 303:1815–1822
pubmed: 20460620
doi: 10.1001/jama.2010.594
Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A (2016) Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern Med 176:175–183
pubmed: 26747333
doi: 10.1001/jamainternmed.2015.7148
Beben T, Ix JH, Shlipak MG, Sarnak MJ, Fried LF, Hoofnagle AN, Chonchol M, Kestenbaum BR, de Boer IH, Rifkin DE (2016) Fibroblast growth factor-23 and frailty in elderly community-dwelling individuals: the Cardiovascular Health Study. J Am Geriatr Soc 64:270–276
pubmed: 26889836
pmcid: 5510331
doi: 10.1111/jgs.13951
De Niet S, Coffiner M, Da Silva S, Jandrain B, Souberbielle JC, Cavalier E (2018) A randomized study to compare a monthly to a daily administration of vitamin D(3) supplementation. Nutrients 10(6):659
Ish-Shalom S, Segal E, Salganik T, Raz B, Bromberg IL, Vieth R (2008) Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. J Clin Endocrinol Metab 93:3430–3435
pubmed: 18544622
doi: 10.1210/jc.2008-0241
Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, Yoshimura N (2010) IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21:1151–1154
pubmed: 20422154
doi: 10.1007/s00198-010-1285-3
Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R (2019) Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis. JAMA Netw Open 2:e1917789
pubmed: 31860103
pmcid: 6991219
doi: 10.1001/jamanetworkopen.2019.17789
Chakhtoura M, Bacha DS, Gharios C et al (2022) Vitamin D supplementation and fractures in adults: a systematic umbrella review of meta-analyses of controlled trials. J Clin Endocrinol Metab 107:882–898
pubmed: 34687206
doi: 10.1210/clinem/dgab742
Balk EM, Adam GP, Langberg VN et al (2017) Global dietary calcium intake among adults: a systematic review. Osteoporos Int 28:3315–3324
pubmed: 29026938
pmcid: 5684325
doi: 10.1007/s00198-017-4230-x
Wan M, Patel A, Patel JP, Rait G, Jones SA, Shroff R (2021) Quality and use of unlicensed vitamin D preparations in primary care in England: retrospective review of national prescription data and laboratory analysis. Br J Clin Pharmacol 87:1338–1346
pubmed: 32803772
doi: 10.1111/bcp.14521
Pilz S, März W, Cashman KD et al (2018) Rationale and plan for vitamin D food fortification: a review and guidance paper. Front Endocrinol (Lausanne) 9:373
pubmed: 30065699
doi: 10.3389/fendo.2018.00373
Jääskeläinen T, Itkonen ST, Lundqvist A et al (2017) The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data. Am J Clin Nutr 105:1512–1520
pubmed: 28490516
doi: 10.3945/ajcn.116.151415
Dunlop E, Kiely ME, James AP, Singh T, Pham NM, Black LJ (2021) Vitamin D food fortification and biofortification increases serum 25-hydroxyvitamin d concentrations in adults and children: an updated and extended systematic review and meta-analysis of randomized controlled trials. J Nutr 151:2622–2635
pubmed: 34113994
doi: 10.1093/jn/nxab180
Adebayo FA, Itkonen ST, Öhman T, Kiely M, Cashman KD, Lamberg-Allardt C, Odin Consortium (2021) Safety of vitamin D food fortification and supplementation: evidence from randomized controlled trials and observational studies. Foods 10(12):3065
Buttriss JL, Lanham-New SA, Steenson S et al (2022) Implementation strategies for improving vitamin D status and increasing vitamin D intake in the UK: current controversies and future perspectives: proceedings of the 2nd Rank Prize Funds Forum on vitamin D. Br J Nutr 127:1567–1587
pubmed: 34284830
doi: 10.1017/S0007114521002555
Harvey NC, Cooper C (2012) Vitamin D: some perspective please. Bmj 345:e4695
pubmed: 22815431
doi: 10.1136/bmj.e4695
WHO (2004) Vitamin and mineral requirements in human nutrition, 2nd edition. In: Nations FAOU (ed) Organization WH. World Health Organization, Geneva
Food and Agriculture Organization of the United Nations (1997) Preventing micronutrient malnutrition: a guide to food-based approaches. ILSI Press, Washington DC
Institute of Medicine (US) (2011) Committee to review dietary reference intakes for vitamin D and calcium. In: Ross AC, Taylor CL, Yaktine AL et al (ed) Dietary reference intakes for calcium and vitamin D. National Academies Press (US), Washington (DC)
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930
pubmed: 21646368
doi: 10.1210/jc.2011-0385
Rizzoli R, Boonen S, Brandi ML, Bruyere O, Cooper C, Kanis JA, Kaufman JM, Ringe JD, Weryha G, Reginster JY (2013) Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin 29:305–313
pubmed: 23320612
doi: 10.1185/03007995.2013.766162
Wilson JMG, Jungner G (1968) Principles and practice of screening for disease. World Health Organization
Chotiyarnwong P, McCloskey EV, Harvey NC et al (2022) Is it time to consider population screening for fracture risk in postmenopausal women? A position paper from the International Osteoporosis Foundation Epidemiology/Quality of Life Working Group. Arch Osteoporos 17:87
pubmed: 35763133
pmcid: 9239944
doi: 10.1007/s11657-022-01117-6
Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB (2022) The health effects of vitamin D supplementation: evidence from human studies. Nat Rev Endocrinol 18:96–110
pubmed: 34815552
doi: 10.1038/s41574-021-00593-z
Grant AM, Avenell A, Campbell MK et al (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365:1621–1628
pubmed: 15885294
doi: 10.1016/S0140-6736(05)63013-9
Manson JE, Bassuk SS, Lee IM et al (2012) The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 33:159–171
pubmed: 21986389
doi: 10.1016/j.cct.2011.09.009
Manson JE, Cook NR, Lee IM et al (2019) Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 380:33–44
pubmed: 30415629
doi: 10.1056/NEJMoa1809944
Bischoff-Ferrari HA, Vellas B, Rizzoli R et al (2020) Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH Randomized Clinical Trial. Jama 324:1855–1868
pubmed: 33170239
pmcid: 7656284
doi: 10.1001/jama.2020.16909
Scragg RKR (2019) Overview of results from the Vitamin D Assessment (ViDA) study. J Endocrinol Investig 42:1391–1399
doi: 10.1007/s40618-019-01056-z
Pittas AG, Dawson-Hughes B, Sheehan P et al (2019) Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med 381:520–530
pubmed: 31173679
pmcid: 6993875
doi: 10.1056/NEJMoa1900906
Priemel M, von Domarus C, Klatte TO et al (2010) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. JBone MinerRes 25:305–312
doi: 10.1359/jbmr.090728
Breth-Petersen M, Bell K, Pickles K, McGain F, McAlister S, Barratt A (2022) Health, financial and environmental impacts of unnecessary vitamin D testing: a triple bottom line assessment adapted for healthcare. BMJ Open 12:e056997
pubmed: 35998953
pmcid: 9472108
doi: 10.1136/bmjopen-2021-056997
Rodd C, Sokoro A, Lix LM, Thorlacius L, Moffatt M, Slater J, Bohm E (2018) Increased rates of 25-hydroxy vitamin D testing: dissecting a modern epidemic. Clin Biochem 59:56–61
pubmed: 30026017
doi: 10.1016/j.clinbiochem.2018.07.005
Rockwell MS, Wu Y, Salamoun M, Hulver MW, Epling JW (2020) Patterns of clinical care subsequent to nonindicated vitamin D testing in primary care. J Am Board Fam Med 33:569–579
pubmed: 32675268
doi: 10.3122/jabfm.2020.04.200007
Gonzalez-Chica D, Stocks N (2019) Changes to the frequency and appropriateness of vitamin D testing after the introduction of new Medicare criteria for rebates in Australian general practice: evidence from 1.5 million patients in the NPS MedicineInsight database. BMJ Open 9:e024797
pubmed: 30852539
pmcid: 6429877
doi: 10.1136/bmjopen-2018-024797
Kahwati LC, LeBlanc E, Weber RP, Giger K, Clark R, Suvada K, Guisinger A, Viswanathan M (2021) Screening for vitamin D deficiency in adults: updated evidence report and systematic review for the US Preventive Services Task Force. Jama 325:1443–1463
pubmed: 33847712
doi: 10.1001/jama.2020.26498
Krist AH, Davidson KW, Mangione CM et al (2021) Screening for vitamin D deficiency in adults: US Preventive Services Task Force recommendation statement. Jama 325:1436–1442
pubmed: 33847711
doi: 10.1001/jama.2021.3069
Zarca K, Durand-Zaleski I, Roux C, Souberbielle JC, Schott AM, Thomas T, Fardellone P, Benhamou CL (2014) Cost-effectiveness analysis of hip fracture prevention with vitamin D supplementation: a Markov micro-simulation model applied to the French population over 65 years old without previous hip fracture. Osteoporos Int 25:1797–1806
pubmed: 24691648
doi: 10.1007/s00198-014-2698-1
Lee RH, Weber T, Colón-Emeric C (2013) Comparison of cost-effectiveness of vitamin D screening with that of universal supplementation in preventing falls in community-dwelling older adults. J Am Geriatr Soc 61:707–714
pubmed: 23631393
pmcid: 3656128
doi: 10.1111/jgs.12213
Jarjou LM, Sawo Y, Goldberg GR, Laskey MA, Cole TJ, Prentice A (2013) Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study. Am J Clin Nutr 98:723–730
pubmed: 23902782
pmcid: 3743734
doi: 10.3945/ajcn.113.061630
Ward KA, Jarjou L, Prentice A (2017) Long-term effects of maternal calcium supplementation on childhood growth differ between males and females in a population accustomed to a low calcium intake. Bone 103:31–38
pubmed: 28583879
pmcid: 5571891
doi: 10.1016/j.bone.2017.06.001