ATP6V1A is required for synaptic rearrangements and plasticity in murine hippocampal neurons.
ATP6V1A
LTP
autophagy
lysosome
neurodevelopment
synapse
v‐ATPase
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
05 Jun 2024
05 Jun 2024
Historique:
revised:
05
05
2024
received:
11
09
2023
accepted:
23
05
2024
medline:
5
6
2024
pubmed:
5
6
2024
entrez:
5
6
2024
Statut:
aheadofprint
Résumé
Understanding the physiological role of ATP6V1A, a component of the cytosolic V Modeling loss of function of Atp6v1a in primary murine hippocampal neurons and studying neuronal morphology and function by immunoimaging, electrophysiological recordings and electron microscopy. Atp6v1a depletion affects neurite elongation, stabilization, and function of excitatory synapses and prevents synaptic rearrangement upon induction of plasticity. These phenotypes are due to an overall decreased expression of the V These data suggest a physiological role of ATP6V1A in the surveillance of synaptic integrity and plasticity and highlight the pathophysiological significance of ATP6V1A loss in the alteration of synaptic function that is associated with neurodevelopmental and neurodegenerative diseases. The data further support the pivotal involvement of lysosomal function and autophagy flux in maintaining proper synaptic connectivity and adaptive neuronal properties.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14186Subventions
Organisme : #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006)-A multiscale inte- grated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022).
Organisme : The Italian Ministry of Health (Ricerca Finalizzata Giovani Ricercatori GR-2019-12 370 176)
Organisme : IRCCS Ospedale Policlinico San Martino (5x1000 and Ricerca Corrente)
Organisme : Tuscany Region Call for Health 2018 (grant DECODE-EE)
Organisme : Fondazione Cassa di Risparmio di Firenze (Human Brain Optical Mapping Project)
Organisme : University of Genoa (Grant D.R. 3404, Heavy Equipment)
Informations de copyright
© 2024 The Author(s). Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.
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