Innate acting memory Th1 cells modulate heterologous diseases.

Th1 Cells / immunology Animals Immunologic Memory / immunology Mice Immunity, Innate Interferon-gamma / metabolism Memory T Cells / immunology Mice, Inbred C57BL Legionella pneumophila / immunology Multiple Sclerosis / immunology Interleukin-12 / metabolism
T helper cells adaptive immunity autoimmunity infection innate

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
11 Jun 2024
Historique:
medline: 5 6 2024
pubmed: 5 6 2024
entrez: 5 6 2024
Statut: ppublish

Résumé

Through immune memory, infections have a lasting effect on the host. While memory cells enable accelerated and enhanced responses upon rechallenge with the same pathogen, their impact on susceptibility to unrelated diseases is unclear. We identify a subset of memory T helper 1 (Th1) cells termed innate acting memory T (T

Identifiants

DOI: 10.1073/pnas.2312837121 PMID: 38838013
pubmed: 38838013
doi: 10.1073/pnas.2312837121
doi:

Substances chimiques

Interferon-gamma 82115-62-6
Interleukin-12 187348-17-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2312837121

Subventions

Organisme : Swiss National Science Foundation
ID : PP00P3_150663
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : PP00P3_181037
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 310030_197590
Pays : Switzerland
Organisme : EC | ERC | HORIZON EUROPE European Research Council (ERC)
ID : 677200
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : PE 2681/1-1
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : SFB-128 Teilprojekt B08

Déclaration de conflit d'intérêts

Competing interests statement:C.R. and J.M.C. are employees of Novartis.

Auteurs

Nikolas Rakebrandt (N)

Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.

Nima Yassini (N)

Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.
Department of Quantitative Biomedicine, University of Zurich, 8057 Zurich, Switzerland.
ORCID: 0000-0003-0844-1276

Anna Kolz (A)

Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München, 82152 Planegg, Germany.
ORCID: 0000-0002-6020-7746

Michelle Schorer (M)

Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.

Katharina Lambert (K)

Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.
ORCID: 0000-0002-1998-0024

Eva Goljat (E)

Department of Quantitative Biomedicine, University of Zurich, 8057 Zurich, Switzerland.
ORCID: 0009-0009-4408-3884

Anna Estrada Brull (A)

Department of Quantitative Biomedicine, University of Zurich, 8057 Zurich, Switzerland.
ORCID: 0009-0002-2470-2974

Celine Rauld (C)

Novartis Biomedical Research, 4002 Basel, Switzerland.
ORCID: 0009-0008-5162-3570

Zsolt Balazs (Z)

Department of Quantitative Biomedicine, University of Zurich, 8057 Zurich, Switzerland.

Michael Krauthammer (M)

Department of Quantitative Biomedicine, University of Zurich, 8057 Zurich, Switzerland.

José M Carballido (JM)

Novartis Biomedical Research, 4002 Basel, Switzerland.
ORCID: 0000-0001-8465-0665

Anneli Peters (A)

Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München, 82152 Planegg, Germany.
Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, 82152 Planegg, Germany.

Nicole Joller (N)

Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.
Department of Quantitative Biomedicine, University of Zurich, 8057 Zurich, Switzerland.
ORCID: 0000-0003-1996-1672

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T mémoire › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Legionellaceae › Legionella › Legionella pneumophila › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Innate acting memory Th1 cells modulate...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-12 › Innate acting memory Th1 cells modulate...