Drug-induced liver injury secondary to tamoxifen.

Humans Tamoxifen / adverse effects Female Chemical and Drug Induced Liver Injury / etiology Middle Aged Breast Neoplasms / drug therapy Antineoplastic Agents, Hormonal / adverse effects Liver / pathology
Gastroenterology Gastrointestinal system Hepatitis other Oncology Unwanted effects / adverse reactions

Journal

BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291

Informations de publication

Date de publication:
05 Jun 2024
Historique:
medline: 6 6 2024
pubmed: 6 6 2024
entrez: 5 6 2024
Statut: epublish

Résumé

Tamoxifen is a non-steroidal selective oestrogen receptor modulator commonly used in the treatment of breast cancer. It is associated with the development of fatty liver and steatohepatitis however drug-induced liver injury is rare. We report a woman in her 50s who developed malaise with an acute moderate aminotransferase elevation without jaundice 6 months after starting tamoxifen. She was not commenced on any other recent drugs and extensive investigation including infective and autoimmune liver screen, cross-sectional imaging and FibroScan were unremarkable. Liver biopsy revealed moderate lobular hepatitis with hepatocyte drop-out. Tamoxifen was ceased and the liver enzymes showed resolution over the following 3 months and improvement of her symptoms.

Identifiants

DOI: 10.1136/bcr-2024-260098 PMID: 38839414
pubmed: 38839414
pii: 17/6/e260098
doi: 10.1136/bcr-2024-260098
pii:
doi:

Substances chimiques

Tamoxifen 094ZI81Y45
Antineoplastic Agents, Hormonal 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Deloshaan Subhaharan (D)

Department of Hepatology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia natalie.commins@gmail.com deloshaan.subhaharan@health.qld.gov.au.

Grace Murphy (G)

Department of Medical Oncology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.

Natalie Commins (N)

Department of Hepatology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia natalie.commins@gmail.com deloshaan.subhaharan@health.qld.gov.au.
ORCID: 0009-0007-5065-030X

Mary Azer (M)

Department of Medical Oncology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Drug-induced liver injury secondary to tamoxifen.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzylidéniques › Stilbènes › Tamoxifène › Drug-induced liver injury secondary to tamoxifen.
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Drug-induced liver injury secondary to tamoxifen.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Drug-induced liver injury secondary to tamoxifen.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Drug-induced liver injury secondary to tamoxifen.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques hormonaux › Drug-induced liver injury secondary to tamoxifen.
questionsmedicales.fr › Système digestif › Foie › Drug-induced liver injury secondary to tamoxifen.