The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.
BRCA1
BRCA2
genetic screening
prostate cancer
psychosocial
quality of life
Journal
BJU international
ISSN: 1464-410X
Titre abrégé: BJU Int
Pays: England
ID NLM: 100886721
Informations de publication
Date de publication:
05 Jun 2024
05 Jun 2024
Historique:
medline:
6
6
2024
pubmed:
6
6
2024
entrez:
5
6
2024
Statut:
aheadofprint
Résumé
To report the long-term outcomes from a longitudinal psychosocial study that forms part of the 'Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls' (IMPACT) study. The IMPACT study is a multi-national study of targeted prostate cancer (PrCa) screening in individuals with a known germline pathogenic variant (GPV) in either the BReast CAncer gene 1 (BRCA1) or the BReast CAncer gene 2 (BRCA2). Participants enrolled in the IMPACT study were invited to complete a psychosocial questionnaire prior to each annual screening visit for a minimum of 5 years. The questionnaire included questions on sociodemographics and the following measures: Hospital Anxiety and Depression Scale, Impact of Event Scale, 36-item Short-Form Health Survey, Memorial Anxiety Scale for PrCa, Cancer Worry Scale, risk perception and knowledge. A total of 760 participants completed questionnaires: 207 participants with GPV in BRCA1, 265 with GPV in BRCA2 and 288 controls (non-carriers from families with a known GPV). We found no evidence of clinically concerning levels of general or cancer-specific distress or poor health-related quality of life in the cohort as a whole. Individuals in the control group had significantly less worry about PrCa compared with the carriers; however, all mean scores were low and within reported general population norms, where available. BRCA2 carriers with previously high prostate-specific antigen (PSA) levels experience a small but significant increase in PrCa anxiety (P = 0.01) and PSA-specific anxiety (P < 0.001). Cancer risk perceptions reflected information provided during genetic counselling and participants had good levels of knowledge, although this declined over time. This is the first study to report the longitudinal psychosocial impact of a targeted PrCa screening programme for BRCA1 and BRCA2 carriers. The results reassure that an annual PSA-based screening programme does not have an adverse impact on psychosocial health or health-related quality of life in these higher-risk individuals. These results are important as more PrCa screening is targeted to higher-risk groups.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Institute of Cancer Research UK
ID : C5047/A21332
Organisme : Institute of Cancer Research UK
ID : C5047/A13232
Organisme : Institute of Cancer Research UK
ID : C5047/A17528
Organisme : Ronald and Rita McAulay Foundation
Organisme : Peacock Charitable Trust
Organisme : NIHR Biomedical Research Centre at The Institute of Cancer Research and Royal Marsden Foundation NHS Trust
Organisme : Oxford Biomedical Research Centre Program
Organisme : NIHR Cambridge Biomedical Research Centre
ID : NIHR203312
Organisme : Manchester University Foundation Trust
ID : IS-BRC-1215-20007
Organisme : Cambridge Clinical Research Centre
Investigateurs
Zsofia Kote-Jarai
(Z)
Audrey Ardern-Jones
(A)
Chris Bangma
(C)
Elena Castro
(E)
David Dearnaley
(D)
Jorunn Eyfjord
(J)
Alison Falconer
(A)
Christopher Foster
(C)
Henrik Grönberg
(H)
Freddie C Hamdy
(FC)
Óskar Þór Jóhannsson
(ÓÞ)
Vincent Khoo
(V)
Hans Lilja
(H)
Geoffrey Lindeman
(G)
Jan Lubinski
(J)
Lovise Maehle
(L)
Alan Millner
(A)
Christos Mikropoulos
(C)
Anita Mitra
(A)
Clare Moynihan
(C)
Judith Offman
(J)
Gad Rennert
(G)
Mohnish Suri
(M)
Penny Wilson
(P)
Jane Melia
(J)
Gillian Mitchell
(G)
Sue Moss
(S)
Fritz Schroder
(F)
Doug Easton
(D)
Susan Peock
(S)
Paul Sibley
(P)
Reza Sharifi
(R)
Paul James
(P)
Sue Shanley
(S)
Kate Richardson
(K)
Joanne McKinley
(J)
Lara Petelin
(L)
Morgan Murphy
(M)
Lyon Mascarenhas
(L)
Katrina Reeve
(K)
Declan Murphy
(D)
Jimmy Lam
(J)
Michael Chong
(M)
Graeme Suthers
(G)
Nicola Poplawski
(N)
Robyn Ward
(R)
Katherine Tucker
(K)
Lesley Andrews
(L)
Rachel Williams
(R)
Jessica Duffy
(J)
Richard Millard
(R)
Tom Jarvis
(T)
Phillip Stricker
(P)
Judy Kirk
(J)
Michelle Bowman
(M)
Manish Patel
(M)
Marion Harris
(M)
Shona O'Connell
(S)
Clare Hunt
(C)
Courtney Smyth
(C)
Mark Frydenberg
(M)
Catherine Morton
(C)
Kylie Shackleton
(K)
Rachel Susman
(R)
Julie McGaughran
(J)
Melanie Boon
(M)
Sharron Townshend
(S)
Lyn Schofield
(L)
Nicholas Pachter
(N)
Allan Spigelman
(A)
Margaret Gleeson
(M)
Rodney Scott
(R)
David Amor
(D)
Jo Burke
(J)
Briony Patterson
(B)
Peter Swindle
(P)
William Foulkes
(W)
Zoulikha Rezoug
(Z)
Leila Feng
(L)
Talia Boshari
(T)
Nassim Taherian
(N)
Armen Aprikian
(A)
Marie Jeanjean
(M)
Thomas Dyrsø Jensen
(TD)
Karina Rønlund
(K)
Palle Osther
(P)
Majbritt Kure Tondering
(MK)
Anne-Marie Gerdes
(AM)
Rita Schmutzler
(R)
Kerstin Rhiem
(K)
Kerstin Luedtke-Heckenkamp
(K)
Petra Wihler
(P)
Nicole Ochsendorf
(N)
Kerstin Fiddike
(K)
Natalie Herold
(N)
K Kast
(K)
S Zastrow
(S)
C Griebsch
(C)
Oskar Johannsson
(O)
Vigdis Stefansdottir
(V)
Vedang Murthy
(V)
Rajiv Sarin
(R)
Pradnya Kowtal
(P)
David Gallagher
(D)
Richard Bambury
(R)
Michael Farrell
(M)
Fergal Gallagher Ingrid Kiernan
(FGI)
Martina Smith
(M)
Siobhan Warren
(S)
Aisling Cahill
(A)
Verena Murphy
(V)
Catherine Fleming
(C)
Elizabeth Morrin
(E)
Rakefet Chen-Shtoyerman
(R)
Alon Basevitch
(A)
Dan Leibovici
(D)
Ehud Melzer
(E)
Sagi Josefsberg Ben-Yehoshua
(SJ)
Eitan Friedman
(E)
Nicola Nicolai
(N)
Paolo Radice
(P)
Riccardo Valdagni
(R)
Tiziana Magnani
(T)
Fabiana Zollo
(F)
Mario Catanzaro
(M)
Margherita Sorrentino
(M)
Simona Gay
(S)
Marco Vitellaro
(M)
Hui Meng Tan
(HM)
Sook-Yee Yoon
(SY)
Soo Hwang Teo
(SH)
Meow Keong Thong
(MK)
Hans Vasen
(H)
Christi van Asperen
(C)
Janneke Ringelberg-Borsboom
(J)
Helen van Randeraad
(H)
Wendy van Zelst-Stams
(W)
Margreet G E M Ausems
(MGEM)
Rob B Van der Luijt
(RB)
Theo van Os
(T)
Mariëlle W G Ruijs
(MWG)
Muriel A Adank
(MA)
Rogier A Oldenburg
(RA)
Jan C Oosterwijk
(JC)
Lovise Mæhle
(L)
Eli Marie Grindedal
(EM)
Eldbjørg Hanslien
(E)
Karol Axcrona
(K)
Cezary Cybulski
(C)
Dominika Wokolorczyk
(D)
Manuel Teixeira
(M)
Sofia Maia
(S)
Marta Cardoso
(M)
Ana Peixoto
(A)
Rui Henrique
(R)
Jorge Oliveira
(J)
Nuno Gonçalves
(N)
Luís Araújo
(L)
João Paulo Souto
(JP)
Pedro Nogueira
(P)
Denisa Ilencikova
(D)
Lucia Copakova
(L)
Janez Zgajnar
(J)
Mateja Krajc
(M)
Alenka Vrecar
(A)
Gabriel Capella
(G)
Teresa Ramón Y Cajal
(T)
Nuria Calvo Verges
(NC)
Josefina Mora
(J)
Joan Palou
(J)
Consol López
(C)
David Fisas
(D)
Alexandra Gisbert
(A)
Judith Balmaña
(J)
Neus Gadea
(N)
Juan Morote
(J)
Annelie Liljegren
(A)
Marie Hjälm-Eriksson
(M)
Karl-Johan Ekdahl
(KJ)
Stefan Carlsson
(S)
Angela George
(A)
Zoe Kemp
(Z)
Jennifer Wiggins
(J)
Cathryn Moss
(C)
Lizzie Verdon
(L)
Nicholas Van As
(N)
Alan Thompson
(A)
Chris Ogden
(C)
Christopher Woodhouse
(C)
Pardeep Kumar
(P)
Declan Cahill
(D)
Karen Tricker
(K)
Barbara Bulman
(B)
Tessy Thomas
(T)
April Ruiz
(A)
Darran Ball
(D)
Oliver Jones
(O)
Catherine Mercer
(C)
Donna McBride
(D)
Philandra Costello Gillian Wise
(PCG)
Allison Pearce
(A)
Victoria Sands
(V)
Audrey Torokwa
(A)
Vincent Gnanapragasam
(V)
Lisa Walker
(L)
Dorothy Halliday
(D)
Emma Stobie
(E)
Helen Purnell
(H)
Barbara Stayner
(B)
Freddie Hamdy
(F)
Heather Chalinor
(H)
Venessa Miller
(V)
Kathryn Saunders
(K)
Helen Hanson
(H)
Merrie Manalo
(M)
Darshna Dudakia
(D)
Audrey Dearing
(A)
Shirley Hodgson
(S)
Glen Brice
(G)
Tessa Homfray
(T)
Carrie Hammond
(C)
Elizabeth Winchester
(E)
Mark Mencias
(M)
Carole Brewer
(C)
Linda Park
(L)
Joanna Ireland
(J)
Alison Potter
(A)
Caroline Renton
(C)
Anne Searle
(A)
Kathryn Hill
(K)
Selina Goodman
(S)
Lynda Garcia
(L)
Gemma Devlin
(G)
Sarah Everest
(S)
Maria Nadolski
(M)
Debbie Fuller
(D)
Catherine Grey
(C)
Melanie Hutchings
(M)
Karin Gupwell
(K)
Maggie Thomas
(M)
Matilda Bradford
(M)
Sandra Cookson
(S)
Lisa Adams
(L)
Hannah Wannell
(H)
Sophie Ashman
(S)
Rachel Kelland
(R)
Edgar Paez
(E)
Alex Henderson
(A)
Fiona Douglas
(F)
Alan Donaldson
(A)
Amy Watford
(A)
Sue Tomkins
(S)
Louise Izatt
(L)
Vishakha Tripathi
(V)
Michelle Weston
(M)
Kathrine Hilario
(K)
Gabriella Pichert
(G)
Chris Jacobs
(C)
Caroline Langman Mark Mencias
(CLM)
Anjana Kulkarni
(A)
Bianca De Souza
(B)
Clare Turnbull
(C)
Alice Youngs
(A)
Cecilia Compton
(C)
Angela Brady
(A)
Virginia Clowes
(V)
Huw Dorkins
(H)
Falak Arshad
(F)
Athalie Melville
(A)
Monika Kosicka-Slawinska
(M)
Carole Cummings
(C)
Vicki Kiesel
(V)
Marion Bartlett
(M)
Kashmir Randhawa
(K)
Natalie Ellery
(N)
Cheryl Sequeira
(C)
Samia Sakuma
(S)
Demetra Georgiou
(D)
Toyin Adeoye
(T)
Munaza Ahmed
(M)
Alison Male
(A)
Jana Gurasashvili
(J)
Kate Simon
(K)
Katie Rees
(K)
Lizzie Tidey
(L)
Laura Coulier
(L)
Camila Gabriel
(C)
Ellen Quinn
(E)
Nita Solanky
(N)
Jennifer Davies
(J)
Pauline Bayliss
(P)
Louise Patterson
(L)
Stuart Ingram
(S)
Kelsey Armitage
(K)
Alice Howell
(A)
Clare Ward
(C)
James Catto
(J)
Joanne Howson
(J)
Jonathan Hoffman
(J)
Camilla Huber
(C)
Madhura Chandrashekara
(M)
Wayne Glover
(W)
Farah Islam
(F)
Saira Ali
(S)
Lucy Burgess
(L)
Cyril Chapman
(C)
Tricia Heaton
(T)
Trevor Cole
(T)
Cathy Watt
(C)
Alexis Duncan
(A)
Nicola Bradshaw
(N)
Lesley Snadden
(L)
Jennifer Gorrie
(J)
Roger Kockelbergh
(R)
Shumi Mzazi
(S)
Charlotte Poile
(C)
Ayisha Sattar
(A)
Beckie Kaemba
(B)
Zahirah Sidat
(Z)
Nafisa Patel
(N)
Kas Siguake
(K)
Amy Branson
(A)
Angela Birt
(A)
Una Poultney
(U)
Nkem Umez-Eronini
(N)
Jaswant Mom
(J)
Beverley Wilkinson
(B)
Michaela Davies
(M)
Rachael O'Keefe
(R)
Anne Johnstone
(A)
Gillian Roberts
(G)
Anthony Woodward
(A)
Vivienne Sutton
(V)
Queenstone Baker
(Q)
Philip Cornford
(P)
Nicola Bermingham Katy Treherne
(NBK)
Julie Griffiths
(J)
Pembe Yesildag
(P)
Hannah Gott
(H)
Maria Brennan
(M)
Natale Salvatore
(N)
Sue Freemantle
(S)
Christina Selkirk
(C)
Peter Hulick
(P)
Wendy Rubinstein
(W)
Charles Brendler
(C)
Karen Kaul
(K)
Daniel Shevrin
(D)
Scott Weissman
(S)
Anna Newlin
(A)
Kristen Vogel
(K)
Shelly Weiss
(S)
Karen O'Toole
(K)
Tom Conner
(T)
Vickie Venne
(V)
Robert Stephenson
(R)
Christopher Dechet
(C)
Susan Domchek
(S)
Jacquelyn Powers
(J)
Banu Arun
(B)
Sara Strom
(S)
John W Davis
(JW)
Yuko Yamamura
(Y)
Elias Obeid
(E)
Lisa Bealin
(L)
Loretta Bagden
(L)
Sue Montgomery
(S)
Veda Giri
(V)
Laura Gross
(L)
Kathy Cooney
(K)
Elena Stoffel
(E)
Linda Okoth
(L)
M Asselman
(M)
H P Beerlage
(HP)
W Blitz
(W)
E R Boevé
(ER)
C A Bout
(CA)
G Commelin
(G)
E B Cornel
(EB)
R J A M Davits
(RJAM)
J A P M de Hond
(JAPM)
G A Dijkman
(GA)
J G Fernandes
(JG)
K B J Fransis
(KBJ)
A D H Geboers
(ADH)
R Gilhuis
(R)
J J P Jaspars
(JJP)
I J Jong
(IJ)
M M G J Jongen-Huinink
(MMGJ)
H F M Karthaus
(HFM)
P J M Kil
(PJM)
P E Kleingeld
(PE)
W J Kniestedt
(WJ)
B C Knipscheer
(BC)
R F Kropman
(RF)
M I Lampe
(MI)
S I Langbein
(SI)
J W H M Langeveld
(JWHM)
J A F Leenarts
(JAF)
M R Leter
(MR)
M T W T Lock
(MTWT)
A H P Meier
(AHP)
B Meijer
(B)
G J Molijn
(GJ)
P F A Mulders
(PFA)
N Naderi
(N)
M A Noordzij
(MA)
J W Noordzij
(JW)
F P P M Pernet
(FPPM)
E P M Roos
(EPM)
M J Schaaf
(MJ)
R J H Schaafsma
(RJH)
G A H J Smits
(GAHJ)
S Smorenburg
(S)
J R Spermon
(JR)
G van Andel
(G)
E van Boven
(E)
C van de Beek
(C)
I W van der Cruijsen-Koeter
(IW)
H G van der Poel
(HG)
O B van Vierssen Trip
(OB)
P D J Vegt
(PDJ)
A P M Verhulst
(APM)
J Verlind
(J)
P Vijverberg
(P)
P A Wertheimer
(PA)
B P Wijsman
(BP)
J V Zambon
(JV)
Informations de copyright
© 2024 The Author(s). BJU International published by John Wiley & Sons Ltd on behalf of BJU International.
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