Too many embryos: a critical perspective on a global challenge.
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
05 Jun 2024
05 Jun 2024
Historique:
received:
07
03
2024
accepted:
24
05
2024
medline:
6
6
2024
pubmed:
6
6
2024
entrez:
5
6
2024
Statut:
aheadofprint
Résumé
Over the past decade, significant endeavors have been directed toward establishing an optimal oocyte number to maximize the chances for successful in vitro fertilization outcomes. The effectiveness of assisted reproductive technologies has greatly improved, and more good-quality embryos are being created in each cycle. However, many of these embryos remain unused. Notably, in Europe, approximately one-third of couples did not use their surplus cryopreserved embryos. Surplus embryos pose a challenge for patients and clinics. Embryo disposal practices are not the same all over the continent, with embryo donation and embryo discharge not allowed in several countries. In this scenario, limiting the number of surplus embryos by reducing the number of inseminated oocytes, according to couple clinical history, could be a strategy.
Identifiants
pubmed: 38839697
doi: 10.1007/s10815-024-03159-w
pii: 10.1007/s10815-024-03159-w
doi:
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Zacà C, Coticchio G, Calesini C, Vigiliano V, Tarozzi N, Lagalla C, Borini A. Towards a more sustainable balance between optimal live birth rate and supernumerary embryos in ART treatments. J Assist Reprod Genet. 2024;41(4):939–46.
Scaravelli G, Zacà C, Levi Setti PE, Livi C, Ubaldi FM, Villani MT, et al. Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles. Fertil Steril. 2021;116(3):766–73.
doi: 10.1016/j.fertnstert.2021.04.006
pubmed: 33972085
Fanton M, Cho JH, Baker VL, Loewke K. A higher number of oocytes retrieved is associated with an increase in fertilized oocytes, blastocysts, and cumulative live birth rates. Fertil Steril. 2023;119(5):762–9.
doi: 10.1016/j.fertnstert.2023.01.001
pubmed: 36634732
Correia KFB, Missmer SA, Weinerman R, Ginsburg ES, Rossi BV. Development of a model to estimate the optimal number of oocytes to attempt to fertilize during assisted reproductive technology treatment. JAMA Netw Open. 2023;6(1):e2249395.
doi: 10.1001/jamanetworkopen.2022.49395
pubmed: 36595292
pmcid: 9857446
Svanberg AS, Boivin J, Hjelmstedt A, Bergh LA, Collins A, Bergh T. The impact of frozen embryos on emotional reactions during in vitro fertilization. Acta Obstet Gynecol Scand. 2001;80(12):1110–4.
doi: 10.1034/j.1600-0412.2001.801206.x
pubmed: 11846707
Moutel G, Gregg E, Meningaud JP, Hervé C. Developments in the storage of embryos in France and the limitations of the laws of bioethics. Analysis of procedures in 17 storage centres and the destiny of stored embryos. Med Law. 2002;21(3):587–604.
pubmed: 12437205
Bangsbøll S, Pinborg A, Yding Andersen C, Nyboe Andersen A. Patients’ attitudes towards donation of surplus cryopreserved embryos for treatment or research. Hum Reprod. 2004;19(10):2415–9.
doi: 10.1093/humrep/deh441
pubmed: 15310730
Christianson MS, Stern JE, Sun F, Zhang H, Styer AK, Vitek W, et al. Embryo cryopreservation and utilization in the United States from 2004–2013. F S Rep. 2020;1(2):71–7.
pubmed: 34223221
pmcid: 8244341
Simopoulou M, Sfakianoudis K, Giannelou P, Rapani A, Maziotis E, Tsioulou P, et al. Discarding IVF embryos: reporting on global practices. J Assist Reprod Genet. 2019;36(12):2447–57.
doi: 10.1007/s10815-019-01592-w
pubmed: 31786731
pmcid: 6911130
Canestrari S. The law of February 19th 2004, 40: procreation and punishment. Rev Derecho Genoma Hum. 2005;(22):57–73.
European IVF Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), Smeenk J, Wyns C, De Geyter C, Kupka M, Bergh C, et al. ART in Europe, 2019: results generated from European registries by ESHRE†. Hum Reprod. 2023;38(12):2321–38.
doi: 10.1093/humrep/dead197
pubmed: 37847771
Chen Y-H, Wang Q, Zhang Y-N, Han X, Li D-H, Zhang C-L. Cumulative live birth and surplus embryo incidence after frozen-thaw cycles in PCOS: how many oocytes do we need? J Assist Reprod Genet. 2017;34(9):1153–9.
doi: 10.1007/s10815-017-0959-6
pubmed: 28580513
pmcid: 5581780
McMahon CA, Saunders DM. Attitudes of couples with stored frozen embryos toward conditional embryo donation. Fertil Steril. 2009;91(1):140–7.
doi: 10.1016/j.fertnstert.2007.08.004
pubmed: 18053994
Hammarberg K, Tinney L. Deciding the fate of supernumerary frozen embryos: a survey of couples’ decisions and the factors influencing their choice. Fertil Steril. 2006;86(1):86–91.
doi: 10.1016/j.fertnstert.2005.11.071
pubmed: 16716313
Tonkens R. The moral unacceptability of abandoning human embryos. Monash Bioeth Rev. 2016;34(1):52–69.
doi: 10.1007/s40592-016-0060-4
pubmed: 27468864
Law 19 February. 2004 No. 40. https://www.gazzettaufficiale.it/eli/id/2004/02/24/004G0062/sg .
Vidal Martínez J. Biomedical research with human embryos: changes in the legislation on assisted reproduction in Spain. Rev Derecho Genoma Hum. 2006 Jul-Dec;(25):161–82.
Feinberg EC, Santoro N, Cedars MI, Amato P. An egg is not a chicken and an embryo is not a child. Fertil Steril. 2024;121(5):752–3. https://doi.org/10.1016/j.fertnstert.2024.03.013 . Epub 2024 Mar 18.
doi: 10.1016/j.fertnstert.2024.03.013
pubmed: 38508507
Correia KFB, Vaughan D, Sakkas D, Rossi BV. Estimating the number of oocytes to expose to sperm in assisted reproductive technology treatment. Fertil Steril. 2024;23:S0015-0282(24)00127-4.
Somigliana E, Parazzini F, Goisis A, Esposito G, Li Piani L, Filippi F, et al. ART and the forgotten siblings: a call for research. Hum Reprod. 2023;38(7):1235–8.
doi: 10.1093/humrep/dead082
pubmed: 37119532
Villanacci R, Buzzaccarini G, Marzanati D, Vanni VS, De Santis L, Alteri A, Candiani M, Pagliardini L, Papaleo E. Delayed blastocyst development is influenced by the level of progesterone on the day of trigger. J Assist Reprod Genet. 2023;40(2):361–70.
doi: 10.1007/s10815-022-02682-y
pubmed: 36542311
Vanni VS, Somigliana E, Reschini M, Pagliardini L, Marotta E, Faulisi S, Paffoni A, Vigano’ P, Vegetti W, Candiani M, Papaleo E. Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF/ICSI cycles. PLoS ONE. 2017;12(5):e0176482.
doi: 10.1371/journal.pone.0176482
pubmed: 28520729
pmcid: 5435161
Papaleo E, Corti L, Vanni VS, Pagliardini L, Ottolina J, De Michele F. al3 basal progesterone level as the main determinant of progesterone elevation on the day of hCG triggering in controlled ovarian stimulation cycles. Arch Gynecol Obstet. 2014;290(1):169–76.
pubmed: 24549270
Bartolacci A, Pagliardini L, Makieva S, Salonia A, Papaleo E, Viganò P. Abnormal sperm concentration and motility as well as advanced paternal age compromise early embryonic development but not pregnancy outcomes: a retrospective study of 1266 ICSI cycles. J Assist Reprod Genet. 2018;35(10):1897–903.
doi: 10.1007/s10815-018-1256-8
pubmed: 29995229
pmcid: 6150884
Mazzilli R, Cimadomo D, Vaiarelli A, Capalbo A, Dovere L, Alviggi E, et al. Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles. Fertil Steril. 2017;108(6):961–e9723.
doi: 10.1016/j.fertnstert.2017.08.033
pubmed: 28985908