Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients with colorectal cancer.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
05 Jun 2024
Historique:
received: 15 11 2023
accepted: 17 05 2024
medline: 6 6 2024
pubmed: 6 6 2024
entrez: 5 6 2024
Statut: epublish

Résumé

Cancer patients often undergo rounds of trial-and-error to find the most effective treatment because there is no test in the clinical practice for predicting therapy response. Here, we conduct a clinical study to validate the zebrafish patient-derived xenograft model (zAvatar) as a fast predictive platform for personalized treatment in colorectal cancer. zAvatars are generated with patient tumor cells, treated exactly with the same therapy as their corresponding patient and analyzed at single-cell resolution. By individually comparing the clinical responses of 55 patients with their zAvatar-test, we develop a decision tree model integrating tumor stage, zAvatar-apoptosis, and zAvatar-metastatic potential. This model accurately forecasts patient progression with 91% accuracy. Importantly, patients with a sensitive zAvatar-test exhibit longer progression-free survival compared to those with a resistant test. We propose the zAvatar-test as a rapid approach to guide clinical decisions, optimizing treatment options and improving the survival of cancer patients.

Identifiants

pubmed: 38839755
doi: 10.1038/s41467-024-49051-0
pii: 10.1038/s41467-024-49051-0
doi:

Substances chimiques

Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4771

Subventions

Organisme : Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation)
ID : FCT-PTDC/MEC-ONC/31627/2017
Organisme : Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation)
ID : LISBOA-01-0145-FEDER-022170

Informations de copyright

© 2024. The Author(s).

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Auteurs

Bruna Costa (B)

Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.

Marta F Estrada (MF)

Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.

António Gomes (A)

Surgery Unit, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.

Laura M Fernandez (LM)

Colorectal Surgery Department, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

José M Azevedo (JM)

Colorectal Surgery Department, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Vanda Póvoa (V)

Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.

Márcia Fontes (M)

Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.

António Alves (A)

Institute of Pathological Anatomy, Faculty of Medicine of the University of Lisbon, Lisbon, Portugal.

António Galzerano (A)

Pathology Service, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Mireia Castillo-Martin (M)

Pathology Service, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Ignacio Herrando (I)

Colorectal Surgery Department, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Shermann Brandão (S)

Digestive Unit, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Carla Carneiro (C)

Surgery Unit, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.

Vítor Nunes (V)

Surgery Unit, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.

Carlos Carvalho (C)

Digestive Unit, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Amjad Parvaiz (A)

Colorectal Surgery Department, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Ana Marreiros (A)

Faculty of Medicine and Biomedical Sciences, University of Algarve, Faro, Portugal.
Algarve Biomedical Center Research Institute, University of Algarve, Faro, Portugal.

Rita Fior (R)

Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal. rita.fior@research.fchampalimaud.org.

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