Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
05 Jun 2024
05 Jun 2024
Historique:
received:
09
03
2023
accepted:
19
04
2024
medline:
6
6
2024
pubmed:
6
6
2024
entrez:
5
6
2024
Statut:
aheadofprint
Résumé
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci eightfold to 164, including three on chromosome X. Sex-specific meta-analyses revealed largely overlapping genetic predispositions of the sexes (r
Identifiants
pubmed: 38839884
doi: 10.1038/s41588-024-01763-1
pii: 10.1038/s41588-024-01763-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 218143125
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 310572679
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 390857198
Investigateurs
Amélie Bonnefond
(A)
Louis Potier
(L)
Informations de copyright
© 2024. The Author(s).
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