Why sedative hypnotics often fail in development.

Journal

Current opinion in anaesthesiology

ISSN: 1473-6500

Titre abrégé: Curr Opin Anaesthesiol

Pays: United States

ID NLM: 8813436

Informations de publication

Date de publication:
06 May 2024

Historique:

medline: 6 6 2024

pubmed: 6 6 2024

entrez: 6 6 2024

Statut: aheadofprint

Résumé

Drug development to support anaesthesia and sedation has been slow with few candidates emerging from preclinical discovery and limited innovation beyond attempted reformulation of existing compounds. The market is well supported by low-cost generic products and development compounds have not been shown to improve patient outcomes or possess other distinctive characteristics to justify the cost of development. To make progress in a large-volume, low margin and highly competitive environment requires meaningful advances in relevant basic science. Opportunities exist, but probably require bolder initiatives than further attempts at reformulation or fiddling with the structure of propofol. Extending development ambitions to include nonanaesthesiologist providers challenges professional boundaries but may facilitate cost-effective changes in patterns of care.

Identifiants

DOI: 10.1097/ACO.0000000000001381 PMID: 38841982

pubmed: 38841982

doi: 10.1097/ACO.0000000000001381

pii: 00001503-990000000-00190

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

Références

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