Remifentanil-induced hyperalgesia: the current state of affairs.

Journal

Current opinion in anaesthesiology

ISSN: 1473-6500

Titre abrégé: Curr Opin Anaesthesiol

Pays: United States

ID NLM: 8813436

Informations de publication

Date de publication:
04 Jun 2024

Historique:

medline: 6 6 2024

pubmed: 6 6 2024

entrez: 6 6 2024

Statut: aheadofprint

Résumé

Remifentanil-induced hyperalgesia (RIH) is a part of a general opioid-induced hyperalgesia (OIH) syndrome, seemingly resulting from abrupt cessation of continuous remifentanil infusion at rates equal or exceeding 0.3 mcg/kg/min. The intricate mechanisms of its development are still not completely understood. However, hyperactivation of the N-methyl d-aspartate receptor system, descending spinal facilitation and increased concentration of dynorphin (a κ-opioid ligand) are commonly proposed as possible mechanisms. Several ways of prevention and management have been suggested, such as slow withdrawal of remifentanil infusion, the addition of propofol, pretreatment with or concomitant administration of ketamine, buprenorphine, cyclooxygenase-2 inhibitors (NSAIDs), methadone, dexmedetomidine. In clinical and animal studies, these strategies exhibited varying success, and many are still being investigated.

Identifiants

DOI: 10.1097/ACO.0000000000001400 PMID: 38841986

pubmed: 38841986

doi: 10.1097/ACO.0000000000001400

pii: 00001503-990000000-00200

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

Références

Angst MS, Clark J. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology 2006; 104:570–587.

Angst MS. Intraoperative use of remifentanil for TIVA: postoperative pain, acute tolerance, and opioid-induced hyperalgesia. J Cardiothorac Vasc Anesth 2015; 29 (S1):S16–S22.

Lee M, Silverman S, Hansen H, et al. A comprehensive review of opioid-induced hyperalgesia. Pain Physician 2011; 14:145–161.

Martinez V, Fletcher D. Prevention of opioid-induced hyperalgesia in surgical patients: does it really matter? Br J Anaesth 2012; 109:302–304.

Kim S, Stoicea N, Soghomonyan S, Bergese SD. Intraoperative use of remifentanil and opioid induced hyperalgesia/acute opioid tolerance: systematic review. Front Pharmacol 2014;5:Article 108.

Davis JJ, Swenson JD, Hall RH, et al. Preoperative “fentanyl challenge” as a tool to estimate postoperative opioid dosing in chronic opioid-consuming patients. Anesth Analg 2005; 101:389–395.

Konopka KH, van Wijhe M. Opioid-induced hyperalgesia: pain hurts? Br J Anaesth 2010; 105:555–557.

Hemmings HC, Egan TD. Pharmacology and physiology for anesthesia. Foundations and clinical application. 2nd ed, Elsevier; 2018.p. 348–9. ISBN 978-0-323-48110-6.

Tompkins DA, Campbell CM. Opioid-induced hyperalgesia: clinically relevant or extraneous research phenomenon? Curr Pain Headache Rep 2011; 15:129–136.

Angst MS, Koppert W, Pahl I, et al. Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain 2003; 106:49–57.

Koppert W, Sittl R, Scheuber K, et al. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology 2003; 99:152–159.

Mao J, Price DD, Mayer DJ. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 1995; 62:259–274.

Chang G, Chen L, Mao J. Opioid tolerance and hyperalgesia. Med Clin North Am 2007; 91:199–211.

Heinricher MM, Morgan MM, Tortorici V, Fields HL. Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla. Neuroscience 1994; 63:279–288.

Vanderah TW, Ossipov MH, Lai J, et al. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain 2001; 92:5–9.

Colvin L, Bull F, Hales T. Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia. Lancet 2019; 393:1558–1568.

Horii Y, Matsuda M, Takemura H, et al. Spinal and peripheral mechanisms individually lead to the development of remifentanil-induced hyperalgesia. Neuroscience 2020;446:28–42.

Deng L, Zhang L, Zhao H, et al. The role of p38MAPK activation in spinal dorsal horn in remifentanil-induced postoperative hyperalgesia in rats. Neurol Res 2016; 38:929–936.

Simonnet G, Rivat C. Opioid-induced hyperalgesia: abnormal or normal pain? Neuroreport 2003; 14:1–7.

Lötsch J. Opioid metabolites. J Pain Symptom Manage 2005; 29:S10–S24.

Armstrong SC, Cozza KL. Pharmacokinetic drug interactions of morphine, codeine and their derivatives: theory and clinical reality. Part II. Psychosomatics 2003; 44:515–520.

Wright AW, Nocente ML, Smith MT. Hydromorphone-3-glucuronider: biosynthesis and preliminary pharmacological evaluation. Life Sci 1998; 63:401–411.

Laulin JP, Maurette P, Corcuff JB, et al. The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphone tolerance. Anesth Analg 2002; 94:1263–1269.

Cooper DW, Lindsay SL, Ryall DM, et al. Does intrathecal fentanyl produce acute cross-tolerance to i.v. morphine? Br J Anaesth 1997; 78:311–313.

Celerier E, Rivat C, Jun Y, et al. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000;92:465–72.

Mao J. Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy. Pain 2002; 100:213–217.

Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology 2000;93:409-17.

Ma J, Huang Z, Li J, et al. Cohort study of remifentanil-induced hyperalgesia in postoperative patients. Zhonghu Yi Xue Za Zhi 2011; 91:977–979.

Manyam SC, Gupta DK, Johnson KB, et al. Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. Anesthesiology 2006; 105:267–278.

Kern SE, Xie G, White JL, Egan TD. A response surface analysis of propofol-remifentanil pharmacodynamic interaction in volunteers. Anesthesiology 2004; 100:1373–1381.

Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology 2000; 93:409–417.

Lee L, Irwin M, Lui S. Intraoperative remifentanil infusion does not increase postoperative opioid consumption compared with 70% nitrous oxide. Anesthesiology 2005; 102:398–402.

Cabañero D, Campillo A, Célérier E, et al. Pronociceptive effects of remifentanil in a mouse model of postsurgical pain: effect of a second surgery. Anesthesiology 2009; 111:1334–1345.

Shin SW, Cho AR, Lee HJ, et al. Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. Br J Anaesth 2010; 105:661–667.

Angst MS. Intraoperative use of remifentanil for TIVA. Postoperative pain, acute tolerance, and opioid-induced hyperalgesia. J Cardiothorac Vasc Anesth 2015; 29 (S 1):S16–S22.

Svensson CK. Opioid-induced hyperalgesia: is it a clinically relevant phenomenon? Int J Pharm Pract 2022; 30:479–483.

Vargas-Schaffer G, Paquet S, Neron A, et al. Opioid induced hyperalgesia, a research phenomenon or a clinical reality? results of a canadian survey. J Pers Med 2020; 10:E27.

Colvin LA, Bull F, Hales TG. Perioperative opioid analgesia-when is enough too much? A review of opioid-induced tolerance and hyperalgesia. Lancet 2019; 393:1558–1568.

Vinik HR, Kissin I. Rapid development of tolerance to analgesia during remifentanil infusion in humans. Anesth Analg 1998; 86:1307–1311.

Koppert W, Angst M, Alsheimer M, et al. Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans. Pain 2003; 106:91–99.

Orser B. Propofol-induced neuroexcitation and receptor desensitization. Can J Anaesth 1994; 41 (Pt 1):366–371.

Singler B, Tröster A, Manering N, et al. Modulation of remifentanil-induced post infusion hyperalgesia by propofol. Anesth Analg 2007; 104:1397–1403.

Comelon M, Raeder J, Stubhaug A, et al. Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia. Br J Anaesth 2016; 116:524–530.

Ramasubbu C, Gupta A. Pharmacological treatment of opioid-induced hyperalgesia: a review of the evidence. J Pain Palliat Care Pharmacother 2011; 25:219–230.

Wilson SH, Hellman KM, James D, et al. Mechanisms, diagnosis, prevention and management of perioperative opioid-induced hyperalgesia. Pain Manag 2021; 11:405–417.

Xie WJ, Hong JS, Feng CF, et al. Pharmacological interventions for preventing opioid-induced hyperalgesia in adults after opioid-based anesthesia: a systematic review and network meta-analysis. Front Pharmacol 2023; 14:1199794.

Joly V, Richebe P, Guignard B, et al. Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 2005; 103:147–155.

Engelhardt T, Zaarour C, Naser B, et al. Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. Anesth Analg 2008; 107:1170–1175.

Leal PC, Salomao R, Brunialti MK, Sakata RK. Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study. J Clin Anesth 2015; 27:331–337.

Koppert W, Ihmsen H, Körber N, et al. Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model. Pain 2005; 118:15–22.

Mercieri M, Palmisani S, De Blasi RA, et al. Low-dose buprenorphine infusion to prevent postoperative hyperalgesia in patients undergoing major lung surgery and remifentanil infusion: a double-blind, randomized, active-controlled trial. Br J Anaesth 2017; 119:792–802.

Martin DP, Samora WP, Beebe AC, et al. Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial. J Anesth 2018; 32:702–708.

Gurbet A, Basagan-Mogol E, Turker G, et al. Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements. Can J Anaesth 2006; 53:646–652.

Zheng Y, Cui S, Liu Y, et al. Dexmedetomidine prevents remifentanil induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit. Brain Res Bull 2012; 87:427–431.

Lee C, Kim YD, Kim JN. Antihyperalgesic effects of dexmedetomidine on high-dose remifentanil-induced hyperalgesia. Korean J Anesthesiol 2013; 64:301–307.

Santonocito C, Noto A, Crimi C, Sanfilippo F. Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies. Local Reg Anesth 2018; 11:15–23.

Tröster A, Sittl R, Singler B, et al. Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. Anesthesiology 2006; 105:1016–1023.